Cationic polymers are the subject of intense research as non-viral gene delivery systems,
due to their flexible properties, facile synthesis, robustness, and proven gene delivery …

Gene therapy has been pursued in the past two decades for treatment of diseases
associated with defective gene expression. The insertion of a therapeutic gene into cells …

The polyplexes which are formed between cationic polymers and DNA through electrostatic
interactions and thus known as polycation/DNA complexes, are by far the most widely used …

The last decade has witnessed enormous research focused on cationic polymers. Cationic
polymers are the subject of intense research as non-viral gene delivery systems, due to their …

Gene transfer to humans requires carriers for the plasmid DNA which canefficiently and
safely carrythe gene into the nucleus of the desired cells. A series of chemically …

Nucleic acid delivery has many applications in basic science, biotechnology, agriculture,
and medicine. One of the main applications is DNA or RNA delivery for gene therapy …

Nucleic acid therapy can achieve lasting and even curative effects through gene
augmentation, gene suppression, and genome editing. However, it is difficult for naked …

Cationic polymers are promising delivery systems for RNAi due to their ease of
manipulation, scale-up conditions and transfection efficiency. However, some properties …

Cationic, polymer-based delivery systems have faced limitations in the systemic delivery of
therapeutic gene drugs due to difficulties in formulation, in vivo stabilization, toxicity and low …

The development of safe and effective gene delivery agents poses a great challenge in the
quest to make human gene therapy a reality. Cationic polymers represent one important …