Förster resonance energy transfer-based kinase mutation phenotyping reveals an aberrant facilitation of Ca2+/calmodulin-dependent CaMKIIα activity in de novo …

H Fujii, H Kidokoro, Y Kondo, M Kawaguchi… - Frontiers in Molecular …, 2022 - frontiersin.org
CaMKIIα plays a fundamental role in learning and memory and is a key determinant of
synaptic plasticity. Its kinase activity is regulated by the binding of Ca2+/CaM and by …

De novo variants in CAMK2A and CAMK2B cause neurodevelopmental disorders

T Akita, K Aoto, M Kato, M Shiina… - Annals of clinical …, 2018 - Wiley Online Library
Objective α (CAMK 2A) and β (CAMK 2B) isoforms of Calcium/calmodulin‐dependent
protein kinase II (Ca MKII) play a pivotal role in neuronal plasticity and in learning and …

De novo mutations in protein kinase genes CAMK2A and CAMK2B cause intellectual disability

S Küry, GM van Woerden, T Besnard, MP Onori… - The American Journal of …, 2017 - cell.com
Calcium/calmodulin-dependent protein kinase II (CAMK2) is one of the first proteins shown
to be essential for normal learning and synaptic plasticity in mice, but its requirement for …

The intellectual disability‐associated CAMK2G p. Arg292Pro mutation acts as a pathogenic gain‐of‐function

M Proietti Onori, B Koopal, DB Everman… - Human …, 2018 - Wiley Online Library
The abundantly expressed calcium/calmodulin‐dependent protein kinase II (CAMK2), alpha
(CAMK2A), and beta (CAMK2B) isoforms are essential for learning and memory formation …

The CaMKII K42M and K42R mutations are equivalent in suppressing kinase activity and targeting

JE Tullis, NL Rumian, CN Brown, KU Bayer - Plos one, 2020 - journals.plos.org
CaMKII is an important mediator of forms of synaptic plasticity that are thought to underly
learning and memory. The CaMKII mutants K42M and K42R have been used …

Quantitative proteomics analysis of CaMKII phosphorylation and the CaMKII interactome in the mouse forebrain

AJ Baucum, BC Shonesy, KL Rose… - ACS chemical …, 2015 - ACS Publications
Ca2+/calmodulin-dependent protein kinase IIα (CaMKIIα) autophosphorylation at Thr286
and Thr305/Thr306 regulates kinase activity and modulates subcellular targeting and is …

A unique de novo gain-of-function variant in CAMK4 associated with intellectual disability and hyperkinetic movement disorder

M Zech, DD Lam, S Weber… - Molecular …, 2018 - molecularcasestudies.cshlp.org
Calcium/calmodulin-dependent protein kinases (CaMKs) are key mediators of calcium
signaling and underpin neuronal health. Although widely studied, the contribution of CaMKs …

CaMKII: claiming center stage in postsynaptic function and organization

JW Hell - Neuron, 2014 - cell.com
While CaMKII has long been known to be essential for synaptic plasticity and learning,
recent work points to new dimensions of CaMKII function in the nervous system, revealing …

[HTML][HTML] Role of calcium/calmodulin-dependent kinase 2 in neurodevelopmental disorders

MP Onori, GM van Woerden - Brain Research Bulletin, 2021 - Elsevier
Neurodevelopmental disorders are a complex and heterogeneous group of neurological
disorders characterized by their early-onset and estimated to affect more than 3% of children …

Differential roles of CaMKII isoforms in phase separation with NMDA receptors and in synaptic plasticity

Q Cai, X Chen, S Zhu, RA Nicoll, M Zhang - Cell Reports, 2023 - cell.com
Calcium calmodulin-dependent kinase II (CaMKII) is critical for synaptic transmission and
plasticity. Two major isoforms of CaMKII, CaMKIIα and CaMKIIβ, play distinct roles in …