Förster resonance energy transfer-based kinase mutation phenotyping reveals an aberrant facilitation of Ca2+/calmodulin-dependent CaMKIIα activity in de novo …
H Fujii, H Kidokoro, Y Kondo, M Kawaguchi… - Frontiers in Molecular …, 2022 - frontiersin.org
CaMKIIα plays a fundamental role in learning and memory and is a key determinant of
synaptic plasticity. Its kinase activity is regulated by the binding of Ca2+/CaM and by …
synaptic plasticity. Its kinase activity is regulated by the binding of Ca2+/CaM and by …
De novo variants in CAMK2A and CAMK2B cause neurodevelopmental disorders
Objective α (CAMK 2A) and β (CAMK 2B) isoforms of Calcium/calmodulin‐dependent
protein kinase II (Ca MKII) play a pivotal role in neuronal plasticity and in learning and …
protein kinase II (Ca MKII) play a pivotal role in neuronal plasticity and in learning and …
De novo mutations in protein kinase genes CAMK2A and CAMK2B cause intellectual disability
Calcium/calmodulin-dependent protein kinase II (CAMK2) is one of the first proteins shown
to be essential for normal learning and synaptic plasticity in mice, but its requirement for …
to be essential for normal learning and synaptic plasticity in mice, but its requirement for …
The intellectual disability‐associated CAMK2G p. Arg292Pro mutation acts as a pathogenic gain‐of‐function
M Proietti Onori, B Koopal, DB Everman… - Human …, 2018 - Wiley Online Library
The abundantly expressed calcium/calmodulin‐dependent protein kinase II (CAMK2), alpha
(CAMK2A), and beta (CAMK2B) isoforms are essential for learning and memory formation …
(CAMK2A), and beta (CAMK2B) isoforms are essential for learning and memory formation …
The CaMKII K42M and K42R mutations are equivalent in suppressing kinase activity and targeting
CaMKII is an important mediator of forms of synaptic plasticity that are thought to underly
learning and memory. The CaMKII mutants K42M and K42R have been used …
learning and memory. The CaMKII mutants K42M and K42R have been used …
Quantitative proteomics analysis of CaMKII phosphorylation and the CaMKII interactome in the mouse forebrain
AJ Baucum, BC Shonesy, KL Rose… - ACS chemical …, 2015 - ACS Publications
Ca2+/calmodulin-dependent protein kinase IIα (CaMKIIα) autophosphorylation at Thr286
and Thr305/Thr306 regulates kinase activity and modulates subcellular targeting and is …
and Thr305/Thr306 regulates kinase activity and modulates subcellular targeting and is …
A unique de novo gain-of-function variant in CAMK4 associated with intellectual disability and hyperkinetic movement disorder
Calcium/calmodulin-dependent protein kinases (CaMKs) are key mediators of calcium
signaling and underpin neuronal health. Although widely studied, the contribution of CaMKs …
signaling and underpin neuronal health. Although widely studied, the contribution of CaMKs …
CaMKII: claiming center stage in postsynaptic function and organization
JW Hell - Neuron, 2014 - cell.com
While CaMKII has long been known to be essential for synaptic plasticity and learning,
recent work points to new dimensions of CaMKII function in the nervous system, revealing …
recent work points to new dimensions of CaMKII function in the nervous system, revealing …
[HTML][HTML] Role of calcium/calmodulin-dependent kinase 2 in neurodevelopmental disorders
MP Onori, GM van Woerden - Brain Research Bulletin, 2021 - Elsevier
Neurodevelopmental disorders are a complex and heterogeneous group of neurological
disorders characterized by their early-onset and estimated to affect more than 3% of children …
disorders characterized by their early-onset and estimated to affect more than 3% of children …
Differential roles of CaMKII isoforms in phase separation with NMDA receptors and in synaptic plasticity
Calcium calmodulin-dependent kinase II (CaMKII) is critical for synaptic transmission and
plasticity. Two major isoforms of CaMKII, CaMKIIα and CaMKIIβ, play distinct roles in …
plasticity. Two major isoforms of CaMKII, CaMKIIα and CaMKIIβ, play distinct roles in …
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