Clostridium difficile infection: early history, diagnosis and molecular strain typing methods

C Rodriguez, J Van Broeck, B Taminiau, M Delmée… - Microbial …, 2016 - Elsevier
Recognised as the leading cause of nosocomial antibiotic-associated diarrhoea, the
incidence of Clostridium difficile infection (CDI) remains high despite efforts to improve …

[HTML][HTML] Typing of Clostridium difficile

JS Brazier - Clinical microbiology and infection, 2001 - Elsevier
Clostridium difficile is primarily recognised as a nosocomially acquired pathogen
manifesting in gastrointestinal disease subsequent to the patient receiving broad-spectrum …

Clostridium difficile: Epidemiology, Pathogenicity, and an Update on the Limitations of and Challenges in Its Diagnosis

AA Alyousef - Journal of AOAC International, 2018 - academic.oup.com
The bacterium originally named Bacillus difficilis was later renamed Clostridium difficile
because of the difficulty associated with its isolation in the laboratory. C. difficile causes …

Molecular typing methods for the epidemiological identification of Clostridium difficile strains

SH Cohen, YJ Tang, J Silva, Jr - Expert review of molecular …, 2001 - Taylor & Francis
Toxigenic Clostridium difficile is the etiologic agent of C. difficile-associated diarrhea
(CDAD), the most common cause of nosocomial diarrhea. Cross-infection between patients …

Clostridium difficile infection: epidemiology, diagnosis and understanding transmission

JSH Martin, TM Monaghan, MH Wilcox - … reviews Gastroenterology & …, 2016 - nature.com
Clostridium difficile infection (CDI) continues to affect patients in hospitals and communities
worldwide. The spectrum of clinical disease ranges from mild diarrhoea to toxic megacolon …

Diagnosis of Clostridium difficile infection: an ongoing conundrum for clinicians and for clinical laboratories

BD Carey-Ann, KC Carroll - Clinical microbiology reviews, 2013 - Am Soc Microbiol
Clostridium difficile is a formidable nosocomial and community-acquired pathogen, causing
clinical presentations ranging from asymptomatic colonization to self-limiting diarrhea to …

Challenges for standardization of Clostridium difficile typing methods

CA Huber, NF Foster, TV Riley… - Journal of clinical …, 2013 - Am Soc Microbiol
Typing of Clostridium difficile facilitates understanding of the epidemiology of the infection.
Some evaluations have shown that certain strain types (for example, ribotype 027) are more …

Clostridium difficile: Diagnosis and the Consequence of Over Diagnosis

HS Lee, K Plechot, S Gohil, J Le - Infectious diseases and therapy, 2021 - Springer
Clostridium difficile infection (CDI) is a leading cause of healthcare-associated infections,
accounting for significant disease burden and mortality. The clinical spectrum of C. difficile …

Community-acquired Clostridium difficile infection: an increasing public health threat

A Gupta, S Khanna - Infection and drug resistance, 2014 - Taylor & Francis
There has been a startling shift in the epidemiology of Clostridium difficile infection over the
last decade worldwide, and it is now increasingly recognized as a cause of diarrhea in the …

Molecular methods for detecting and typing of Clostridium difficile

DA Collins, B Elliott, TV Riley - Pathology-Journal of the RCPA, 2015 - journals.lww.com
Since the early 2000s, Clostridium difficile has emerged as a major international pathogen.
Recently, strains of C. difficile in circulation appear to be changing, with greater diversity …