Parkinson's disease (PD) is the second most common progressive age-related
neurodegenerative disorder. Paramount evidence shed light on the role of PI3K/AKT …

Recently, phosphodiesterases (PDEs) have gained great attention due to their implication in
Parkinson's disease (PD) pathogenesis. Noteworthy, the PDE4 enzyme is highly expressed …

Isolongifolene (ILF), a novel tricyclic sesquiterpene compound isolated from the Indian herb
Murraya koenigii (M. koenigii), has been previously demonstrated to have a neuroprotective …

Neuroinflammation induced by activation of the high mobility group box 1/toll-like receptor 4
(HMGB1/TLR4) axis is one of the principal mechanisms involved in dopaminergic neuronal …

Abstract Inhibition of phosphodiesterase 4 (PDE4) is a promising pharmacological strategy
for the treatment of cerebral ischemic conditions. To increase the relevance and increase the …

Abstract Ethnopharmacological relevance Fructus Gardeniae, with the effects of discharging
fire, eliminating vexation, reducing fever and causing diuresis, and cooling blood to remove …

Objective: Fasudil, a Rho kinase inhibitor, has neuroprotection in the 1-methyl-4-phenyl-1, 2,
3, 6-tetrahydropyridine (MPTP)-based Parkinson's disease (PD). This study aims to …

Pesticides exposure can lead to damage of dopaminergic neurons, which are associated
with increased risk of Parkinson's disease (PD). However, the etiology of PD remains poorly …

Recent studies have demonstrated that activation of the Rho-associated kinase (ROCK)
pathway participates in the dopaminergic neuron degeneration and possibly in Parkinson's …

Huntington's disease (HD) is a progressive neurodegenerative and hyperkinetic movement
disorder. Decreased activity of cAMP-responsive element-binding protein (CREB) is thought …