Rho kinases and cardiac remodeling
T Shimizu, JK Liao - Circulation Journal, 2016 - jstage.jst.go.jp
Hypertensive cardiac remodeling is characterized by left ventricular hypertrophy and
interstitial fibrosis, which can lead to heart failure with preserved ejection fraction. The Rho …
interstitial fibrosis, which can lead to heart failure with preserved ejection fraction. The Rho …
Rho kinase as a therapeutic target in cardiovascular disease
Rho kinase (ROCK) belongs to the AGC (PKA/PKG/PKC) family of serine/threonine kinases
and is a major downstream effector of the small GTPase RhoA. ROCK plays central roles in …
and is a major downstream effector of the small GTPase RhoA. ROCK plays central roles in …
Rho kinase signaling and cardiac physiology
Highlights•Rho kinase signaling plays important roles in the cardiovascular system.•Rho
kinase signaling mediates cardiac hypertrophy, apoptosis and fibrosis.•Rho kinase signaling …
kinase signaling mediates cardiac hypertrophy, apoptosis and fibrosis.•Rho kinase signaling …
Targeting Rho-associated coiled-coil forming protein kinase (ROCK) in cardiovascular fibrosis and stiffening
Introduction: Pathological cardiac fibrosis, through excessive extracellular matrix protein
deposition from fibroblasts and pro-fibrotic immune responses and vascular stiffening is …
deposition from fibroblasts and pro-fibrotic immune responses and vascular stiffening is …
Rho kinases in cardiovascular physiology and pathophysiology: the effect of fasudil
Rho kinase (ROCK) is a major downstream effector of the small GTPase RhoA. ROCK
family, consisting of ROCK1 and ROCK2, plays central roles in the organization of actin …
family, consisting of ROCK1 and ROCK2, plays central roles in the organization of actin …
Rho kinase as potential therapeutic target for cardiovascular diseases: opportunities and challenges
E Hu, D Lee - Expert Opinion on Therapeutic Targets, 2005 - Taylor & Francis
Rho kinase (ROCK) belongs to a family of Ser/Thr protein kinases that are activated via
interaction with the small GTP-binding protein RhoA. Growing evidence suggests that RhoA …
interaction with the small GTP-binding protein RhoA. Growing evidence suggests that RhoA …
The function of Rho-associated kinases ROCK1 and ROCK2 in the pathogenesis of cardiovascular disease
S Hartmann, AJ Ridley, S Lutz - Frontiers in pharmacology, 2015 - frontiersin.org
Rho-associated kinases ROCK1 and ROCK2 are serine/threonine kinases that are
downstream targets of the small GTPases RhoA, RhoB, and RhoC. ROCKs are involved in …
downstream targets of the small GTPases RhoA, RhoB, and RhoC. ROCKs are involved in …
Small guanine nucleotide-binding protein Rho and myocardial function
RhoA and Rho-kinase (ROCK) participate in a wide variety of cell signal functions such as
cell growth, smooth and cardiac muscle contraction, cytoskeleton rearrangement, cell …
cell growth, smooth and cardiac muscle contraction, cytoskeleton rearrangement, cell …
Decreased Perivascular Fibrosis but Not Cardiac Hypertrophy in ROCK1+/− Haploinsufficient Mice
Y Rikitake, N Oyama, CYC Wang, K Noma, M Satoh… - Circulation, 2005 - Am Heart Assoc
Background—Rho GTPase and its downstream target, Rho-associated kinase (ROCK),
have been implicated in diverse cardiovascular diseases such as cardiac hypertrophy …
have been implicated in diverse cardiovascular diseases such as cardiac hypertrophy …
Rho kinases in cardiovascular physiology and pathophysiology
Rho kinases (ROCKs) are the first and the best-characterized effectors of the small G-protein
RhoA. In addition to their effect on actin organization, or through this effect, ROCKs have …
RhoA. In addition to their effect on actin organization, or through this effect, ROCKs have …