Nuclear targeting of a bacterial integrase that mediates site-specific recombination between bacterial and human target sequences

L Agúndez, C Machón, CE César… - Applied and …, 2011 - Am Soc Microbiol
TrwC is a bacterial protein involved in conjugative transfer of plasmid R388. It is transferred
together with the DNA strand into the recipient bacterial cell, where it can integrate the …

The conjugative relaxase TrwC promotes integration of foreign DNA in the human genome

C González-Prieto, R Gabriel, C Dehio… - Applied and …, 2017 - Am Soc Microbiol
Bacterial conjugation is a mechanism of horizontal DNA transfer. The relaxase TrwC of the
conjugative plasmid R388 cleaves one strand of the transferred DNA at the oriT gene …

Site-specific integration of foreign DNA into minimal bacterial and human target sequences mediated by a conjugative relaxase

L Agúndez, C González-Prieto, C Machón, M Llosa - PloS one, 2012 - journals.plos.org
Background Bacterial conjugation is a mechanism for horizontal DNA transfer between
bacteria which requires cell to cell contact, usually mediated by self-transmissible plasmids …

Characterization of a conjugative transposon integrase, IntDOT

K Malanowska, AA Salyers… - Molecular …, 2006 - Wiley Online Library
Sequence analysis revealed that the integrase of the Bacteroides conjugative transposon
CTnDOT (IntDOT) might be a member of the tyrosine recombinase family because IntDOT …

Conjugative transposition of Tn916 requires the excisive and integrative activities of the transposon-encoded integrase

MJ Storrs, C Poyart-Salmeron, P Trieu-Cuot… - Journal of …, 1991 - Am Soc Microbiol
Transposon Tn916 is a 16.4-kb broad-host-range conjugative transposon originally detected
in the chromosome of Enterococcus faecalis DS16. Transposition of Tn916 and related …

Characterization of the integrase of NBU1, a Bacteroides mobilizable transposon

L Rajeev, AA Salyers, JF Gardner - Molecular microbiology, 2006 - Wiley Online Library
NBU1 is a Bacteroides mobilizable transposon (MTn) that is integrated within the host
chromosome and requires CTnDOT functions for its excision and transfer into a new host …

Integration Site Selection by the Bacteroides Conjugative Transposon CTnBST

B Song, NB Shoemaker, JF Gardner… - Journal of …, 2007 - Am Soc Microbiol
ABSTRACT A newly discovered Bacteroides conjugative transposon (CTn), CTnBST,
integrates more site specifically than two other well-studied CTns, the Bacteroides CTn …

The bacteroides NBU1 integrase performs a homology-independent strand exchange to form a holliday junction intermediate

L Rajeev, A Segall, J Gardner - Journal of biological chemistry, 2007 - ASBMB
The Bacteroides mobilizable transposon NBU1 uses an integrase (IntN1) that is a tyrosine
recombinase for its integration and excision from the host chromosome. Previously we …

NBU1 integrase: evidence for an altered recombination mechanism

JW Schmidt, L Rajeev, AA Salyers… - Molecular …, 2006 - Wiley Online Library
Summary NBU1 is a 10.3 kbp Bacteroides mobilizable transposon. A previous study had
identified a 2.7 kbp segment of the excised circular intermediate that was sufficient to …

Human genomic site-specific recombination catalyzed by coliphage HK022 integrase

G Harel-Levi, J Goltsman, CNJH Tuby, E Yagil… - Journal of …, 2008 - Elsevier
It has been previously demonstrated that the wild type integrase (Int) protein of coliphage
HK022 can catalyze site-specific recombination in human cells between attachment (att) …