J. Neurochem.(2011) 116, 734–741. Abstract The Cys‐loop receptor family consists of
nicotinic acetylcholine receptors (nAChR), glycine receptor, GABA‐A and some other …

Acetylcholine-binding protein is a water-soluble homologue of the extracellular ligand-
binding domain of cys-loop receptors. It is used as a structurally accessible prototype for …

Binding of a neurotransmitter to its ionotropic receptor opens a distantly located ion channel,
a process termed allosteric activation. Here we review recent advances in the molecular …

The nicotinic acetylcholine (ACh) receptors and the other neurotransmitter-gated ion
channels have key roles in fast synaptic transmission throughout the nervous system. These …

Neurotransmitter receptors of the Cys-loop superfamily mediate rapid synaptic transmission
throughout the nervous system, and include receptors activated by ACh, GABA, glycine and …

The nicotinic acetylcholine receptor is the neurotransmitter receptor with the most‐
characterized protein structure. The amino acid sequences of its five subunits have been …

The nicotinic acetylcholine receptor and related Cys-loop receptors are ligand-gated ion
channels that mediate fast synaptic transmission throughout the central and peripheral …

New hypotheses and predictions have arisen from recent work revealing atomic-scale or
near-atomic-scale structures of receptors in the 'Cys-loop'superfamily. How general is the …

Nicotinic acetylcholine receptors (AChRs) are one of the best characterized ion channels
from the Cys-loop receptor superfamily. The study of acetylcholine binding proteins and …

Rapid neurotransmission is mediated through a superfamily of Cys-loop receptors that
includes the nicotinic acetylcholine (nAChR), γ-aminobutyric acid (GABAA), serotonin (5 …