Cell plasticity and neuroendocrine differentiation in prostate and lung adenocarcinomas are
one of the major reasons for therapeutic resistance to targeted therapy. Whether and how …

Regardless of the recent advances in therapeutic developments, cancer is still among the
primary causes of death globally, indicating the need for alternative therapeutic strategies …

Mitochondria are dynamic organelles that have essential metabolic activity and are
regarded as signalling hubs with biosynthetic, bioenergetics and signalling functions that …

One of the remarkable features of cancer cells is aerobic glycolysis, a phenomenon known
as the “Warburg Effect”, in which cells rely preferentially on glycolysis instead of oxidative …

To adapt to tumoral environment conditions or even to escape chemotherapy, cells rapidly
reprogram their metabolism to handle adversities and survive. Given the rapid rise of studies …

The challenge of rapid macromolecular synthesis enforces the energy-hungry cancer cell
mitochondria to switch their metabolic phenotypes, accomplished by activation of oncogenic …

Altered metabolism is a distinct feature of cancer cells. During transformation, the entire
metabolic network is rewired to efficiently convert nutrients to biosynthetic precursors to …

Mitochondria are dynamic organelles that have been linked to stem cell homeostasis.
However, the mechanisms involved in mitochondrial regulation of stem cell fate …

Mitochondria are crucial cellular organelles. Under extracellular stimulations, mitochondria
undergo constant fusion and fission dynamics to meet different cellular demands …

Dysregulating cellular metabolism is one of the emerging cancer hallmarks. Mitochondria
are essential organelles responsible for numerous physiologic processes, such as energy …