In type 1 diabetes, T cell-mediated death of pancreatic β cells produces insulin deficiency.
However, what attracts or restricts broadly autoreactive lymphocyte pools to the pancreas …

The capsaicin receptor transient receptor potential vanilloid subfamily member 1 (TRPV1) is
highly expressed on sensory nerve fibers innervating the pancreas. Indeed, the role of …

Pancreatic islets of Langerhans are enveloped by peri-islet Schwann cells (pSC), which
express glial fibrillary acidic protein (GFAP) and S100β. pSC-autoreactive T-and B-cell …

Inflammation can activate self-reactive CD8+ T cells and induce autoimmunity. Here we
show in a CD8+ T cell-mediated model of type 1 diabetes that CD4+ CD25+ Treg cells …

Background And Aims Destroying visceral sensory nerves impacts pancreatic islet function,
glucose metabolism, and diabetes onset, but how islet endocrine cells interact with sensory …

Objective To test the hypotheses that:(1) the transient receptor potential vanilloid 4 (TRPV4)
ion channel is protective in the obesity model of osteoarthritis (OA), resulting in more severe …

Regulatory T cells (Tregs) control organ-specific autoimmunity in a tissue antigen-specific
manner, yet little is known about their specificity in a natural repertoire. In this study, we used …

Type 1 diabetes develops over many years and is characterized ultimately by the destruction
of insulin-producing pancreatic beta cells by autoreactive T cells. Nonetheless, the role of …

Insulin secretion from pancreatic β-cells is the only efficient means to decrease blood
glucose concentrations. Glucose is the principal stimulator of insulin secretion with the ATP …

Obesity induced by Western diets is associated with type 2 diabetes mellitus and
cardiovascular diseases, although underlying mechanisms are unclear. We investigated a …