[HTML][HTML] TRPV1+ sensory neurons control β cell stress and islet inflammation in autoimmune diabetes
R Razavi, Y Chan, FN Afifiyan, XJ Liu, X Wan, J Yantha… - Cell, 2006 - cell.com
In type 1 diabetes, T cell-mediated death of pancreatic β cells produces insulin deficiency.
However, what attracts or restricts broadly autoreactive lymphocyte pools to the pancreas …
However, what attracts or restricts broadly autoreactive lymphocyte pools to the pancreas …
The emerging role of TRPV1 in diabetes and obesity
A Suri, A Szallasi - Trends in pharmacological sciences, 2008 - cell.com
The capsaicin receptor transient receptor potential vanilloid subfamily member 1 (TRPV1) is
highly expressed on sensory nerve fibers innervating the pancreas. Indeed, the role of …
highly expressed on sensory nerve fibers innervating the pancreas. Indeed, the role of …
Autoimmune islet destruction in spontaneous type 1 diabetes is not β-cell exclusive
S Winer, H Tsui, A Lau, A Song, X Li, RK Cheung… - Nature medicine, 2003 - nature.com
Pancreatic islets of Langerhans are enveloped by peri-islet Schwann cells (pSC), which
express glial fibrillary acidic protein (GFAP) and S100β. pSC-autoreactive T-and B-cell …
express glial fibrillary acidic protein (GFAP) and S100β. pSC-autoreactive T-and B-cell …
[HTML][HTML] Pancreatic lymph node-derived CD4+ CD25+ Treg cells: highly potent regulators of diabetes that require TRANCE-RANK signals
EA Green, Y Choi, RA Flavell - Immunity, 2002 - cell.com
Inflammation can activate self-reactive CD8+ T cells and induce autoimmunity. Here we
show in a CD8+ T cell-mediated model of type 1 diabetes that CD4+ CD25+ Treg cells …
show in a CD8+ T cell-mediated model of type 1 diabetes that CD4+ CD25+ Treg cells …
Pancreatic β-cells communicate with vagal sensory neurons
Background And Aims Destroying visceral sensory nerves impacts pancreatic islet function,
glucose metabolism, and diabetes onset, but how islet endocrine cells interact with sensory …
glucose metabolism, and diabetes onset, but how islet endocrine cells interact with sensory …
Increased susceptibility of Trpv4-deficient mice to obesity and obesity-induced osteoarthritis with very high-fat diet
CJ O'conor, TM Griffin, W Liedtke… - Annals of the rheumatic …, 2013 - ard.bmj.com
Objective To test the hypotheses that:(1) the transient receptor potential vanilloid 4 (TRPV4)
ion channel is protective in the obesity model of osteoarthritis (OA), resulting in more severe …
ion channel is protective in the obesity model of osteoarthritis (OA), resulting in more severe …
Revealing the specificity of regulatory T cells in murine autoimmune diabetes
A Spence, W Purtha, J Tam, S Dong… - Proceedings of the …, 2018 - National Acad Sciences
Regulatory T cells (Tregs) control organ-specific autoimmunity in a tissue antigen-specific
manner, yet little is known about their specificity in a natural repertoire. In this study, we used …
manner, yet little is known about their specificity in a natural repertoire. In this study, we used …
Crosstalk between neutrophils, B-1a cells and plasmacytoid dendritic cells initiates autoimmune diabetes
J Diana, Y Simoni, L Furio, L Beaudoin, B Agerberth… - Nature medicine, 2013 - nature.com
Type 1 diabetes develops over many years and is characterized ultimately by the destruction
of insulin-producing pancreatic beta cells by autoreactive T cells. Nonetheless, the role of …
of insulin-producing pancreatic beta cells by autoreactive T cells. Nonetheless, the role of …
The role of thermosensitive TRP (transient receptor potential) channels in insulin secretion
K Uchida, M Tominaga - Endocrine journal, 2011 - jstage.jst.go.jp
Insulin secretion from pancreatic β-cells is the only efficient means to decrease blood
glucose concentrations. Glucose is the principal stimulator of insulin secretion with the ATP …
glucose concentrations. Glucose is the principal stimulator of insulin secretion with the ATP …
A role for TRPV1 in influencing the onset of cardiovascular disease in obesity
NJ Marshall, L Liang, J Bodkin, C Dessapt-Baradez… - …, 2013 - Am Heart Assoc
Obesity induced by Western diets is associated with type 2 diabetes mellitus and
cardiovascular diseases, although underlying mechanisms are unclear. We investigated a …
cardiovascular diseases, although underlying mechanisms are unclear. We investigated a …