Whole-body health relies on complex inter-organ signalling networks that enable organisms
to adapt to environmental perturbations and to changes in tissue homeostasis. The intestine …

In all metazoans, the intestinal tract is an essential organ to integrate nutritional signaling,
hormonal cues and immunometabolic networks. The dysregulation of intestinal epithelium …

Multicellular organisms have evolved organs and tissues with highly specialized tasks. For
instance, nutrients are assimilated by the gut, sensed, processed, stored, and released by …

Recent findings concerning Drosophila melanogaster intestinal pathology suggest that this
model is well suited for the study of intestinal stem cell physiology during aging, stress and …

Physiological responses are the ultimate outcomes of the functional interactions and proper
organization of the different cell types that make up an organ. The digestive tract represents …

The intestine, as a barrier epithelium, serves in the first line of defense against invading
pathogens and damaging agents that enter the body via food ingestion. Maintenance of …

The long-term maintenance of an organism's homeostasis and health relies on the accurate
regulation of organ-organ communication. Recently, there has been growing interest in …

The digestive tract is subjected to many aggressions throughout animal life. Since
disruptions of gut physiology impact on animal fitness and survival, maintenance of gut …

As a barrier epithelium, the intestinal epithelium has to coordinate physiological functions
like digestion and nutrient resorption with the control of commensal bacteria and the …

Millions of people suffer from inflammatory diseases of the intestine, some of them
potentiating gastrointestinal cancer. These gut-associated pathologies arise from …