Recent studies call into question the necessity of hypertrophic growth of the heart as a
“compensatory” response to hemodynamic stress. These findings, coupled with recent …

▪ Abstract Cardiac hypertrophy is the heart's response to a variety of extrinsic and intrinsic
stimuli that impose increased biomechanical stress. While hypertrophy can eventually …

Myocardial hypertrophy is a response of cardiac muscle to altered conditions of
haemodynamic overload caused by a large number of physiological and pathological …

Cardiomyocytes exit the cell cycle and become terminally differentiated soon after birth.
Therefore, in the adult heart, instead of an increase in cardiomyocyte number, individual …

▪ Abstract This review discusses the rapidly progressing field of cardiomyocyte signal
transduction and the regulation of the hypertrophic response. When stimulated by a wide …

Cardiac hypertrophy leads to heart failure, and both conditions can ultimately prove lethal.
Here, traditional and novel mechanisms relating hypertrophy and heart failure are described …

Throughout the past decade, much effort has been spent on deciphering the signaling
pathways positively mediating cardiac hypertrophy. Recently, several endogenous …

Ventricular hypertrophy is an ominous escalation of hemodynamically stressful conditions
such as hypertension and valve disease. The pathophysiology of hypertrophy is complex …

The mammalian heart during its development and in response to physiological or
pathological stimuli undergoes hypertrophic enlargement, a consequence of an increase in …

Heart failure is one of the leading causes of mortality in the western world and encompasses
a wide spectrum of cardiac pathologies. When the heart experiences extended periods of …