Within the heterogeneous tissue architecture, a comprehensive understanding of how cell
shapes regulate cytoskeletal mechanics by adjusting focal adhesions (FAs) signals to …

One of the recent paradigm shifts in stem cell biology has been the discovery that stem cells
can begin to differentiate into mature tissue cells when exposed to intrinsic properties of the …

Human bone marrow-derived mesenchymal stem cell (hMSCs) function depends on
chemical factors and also on the physical cues of the microenvironmental niche. Here, this …

The spatial boundary condition (SBC) arising from the surrounding microenvironment
imposes specific geometry and spatial constraints that affect organogenesis and tissue …

Stem cell behaviors are regulated by multiple microenvironmental cues. As an external
signal, mechanical stiffness of the extracellular matrix is capable of governing stem cell fate …

Stem cells have been predicted to improve disease outcomes and patient lives. Steering
stem cell fate-through controlling cell shape-may substantially accelerate progress towards …

There is a growing appreciation for the functional role of matrix mechanics in regulating stem
cell self-renewal and differentiation processes. However, it is largely unknown how …

Mesenchymal stem cells (MSCs) hold great potential for regenerative medicine and tissue-
engineering applications. They have multipotent differentiation capabilities and have been …

Adult stem cells hold great promise as a source of diverse terminally differentiated cell types
for tissue engineering applications. However, due to the complexity of chemical and …

Extracellular matrix (ECM) is comprised of different types of proteins, which change in
composition and ratios during morphogenesis and disease progression. ECM proteins …