Cardioprotective microRNAs: Lessons from stem cell-derived exosomal microRNAs to treat cardiovascular disease

AS Moghaddam, JT Afshari, SA Esmaeili, E Saburi… - Atherosclerosis, 2019 - Elsevier
The stem cell-based therapy has emerged as a promising therapeutic strategy for treating
cardiovascular ischemic diseases (CVIDs), such as myocardial infarction (MI). However …

Therapeutic angiogenesis with exosomal microRNAs: an effectual approach for the treatment of myocardial ischemia

T Moghiman, B Barghchi, SA Esmaeili… - Heart Failure …, 2021 - Springer
Therapeutic angiogenesis presents a potential approach for treating ischemic heart
diseases especially in patients who are not appropriate candidates for traditional …

[HTML][HTML] Mesenchymal stem cell-derived exosome microRNA as therapy for cardiac ischemic injury

MI Nasser, M Masood, S Adlat, D Gang, S Zhu… - Biomedicine & …, 2021 - Elsevier
Cardiovascular diseases (CVD) are a significant cause of human health harm. In the past,
stem cell therapy was reported to have functional defects, such as immune rejection …

Mesenchymal stem cell therapy: A promising cell‐based therapy for treatment of myocardial infarction

AES Shafei, MA Ali, HG Ghanem… - The journal of gene …, 2017 - Wiley Online Library
For decades, mesenchymal stem (MSCs) cells have been used for cardiovascular diseases
as regenerative therapy. This review is an attempt to summarize the types of MSCs involved …

Role of microRNAs in stem/progenitor cells and cardiovascular repair

P Jakob, U Landmesser - Cardiovascular research, 2012 - academic.oup.com
Abstract MicroRNAs (miRNAs), small non-coding RNAs, play a critical role in differentiation
and self-renewal of pluripotent stem cells, as well as in differentiation of cardiovascular …

[HTML][HTML] Exosomal miR-218-5p/miR-363-3p from endothelial progenitor cells ameliorate myocardial infarction by targeting the p53/JMY signaling pathway

X Ke, R Yang, F Wu, X Wang, J Liang, X Hu… - Oxidative medicine and …, 2021 - hindawi.com
Accumulating evidence has shown that endothelial progenitor cell-derived exosomes (EPC-
Exos) can ameliorate myocardial fibrosis. The purpose of the present study was to …

Exosomal miR-25-3p from mesenchymal stem cells alleviates myocardial infarction by targeting pro-apoptotic proteins and EZH2

Y Peng, JL Zhao, ZY Peng, WF Xu, GL Yu - Cell Death & Disease, 2020 - nature.com
Mesenchymal stem cell (MSC) therapy is a promising approach against myocardial
infarction (MI). Studies have demonstrated that MSCs can communicate with other cells by …

Exosomal miR-21a-5p mediates cardioprotection by mesenchymal stem cells

KM Luther, L Haar, M McGuinness, Y Wang… - Journal of molecular and …, 2018 - Elsevier
Though experimental, stem cell transplantation has the potential to improve the condition of
the heart after myocardial infarction. It does so by reducing infarct size and inducing repair of …

Mesenchymal stem cell-derived exosomal microRNA-182-5p alleviates myocardial ischemia/reperfusion injury by targeting GSDMD in mice

R Yue, S Lu, Y Luo, J Zeng, H Liang, D Qin… - Cell death …, 2022 - nature.com
Recent evidence indicates that exosomes derived from mesenchymal stem cells (MSCs)
confer protective effects against myocardial ischemia/reperfusion (I/R) injury. Exosomes are …

[HTML][HTML] The role of exosomes and exosomal microRNA in cardiovascular disease

D Zheng, M Huo, B Li, W Wang, H Piao… - Frontiers in cell and …, 2021 - frontiersin.org
Exosomes are small vesicles (30–150 nm in diameter) enclosed by a lipid membrane
bilayer, secreted by most cells in the body. They carry various molecules, including proteins …