OBJECTIVE: Although osteoarthritis (OA) is considered a non-inflammatory condition, it is
widely accepted that synovial inflammation is a feature of OA. However, the role of immune …

Effective treatment of osteoarthritis (OA) remains a huge clinical challenge despite major
research efforts. Different tissues and cell-types within the joint contribute to disease …

Abstract Purpose of the Review Mounting evidence supports a role of low-grade
inflammation in the pathophysiology of osteoarthritis (OA). We review and discuss the role of …

Background Chronic, low-grade inflammation of the synovium (synovitis) is a hallmark of
osteoarthritis (OA), thus understanding of OA immunobiology, mediated by immune …

Understanding the molecular drivers and feedback loops of osteoarthritis (OA) may provide
future therapeutic strategies to modulate the disease progression. The current paradigm of …

Objective It has been suggested that osteoarthritis (OA) is induced by mechanical stress
followed by cartilage destruction, and it is generally accepted that there is little involvement …

Osteoarthritis (OA) is considered a degenerative joint disorder caused by mechanical wear
to the articular surface. However, while joint injury, obesity, and mutations in collagen …

Background The aim of the study was to characterize synovial cells from OA synovium with
low-grade and moderate-grade synovitis and to define the role of synovial macrophages in …

Osteoarthritis (OA) has traditionally been classified as a noninflammatory arthritis; however,
the dichotomy between inflammatory and degenerative arthritis is becoming less clear with …

Introduction This study aimed to evaluate whether profiles of several soluble mediators in
synovial fluid and cartilage tissue are pathology-dependent and how their production is …