The concept of immune privilege suggests that the central nervous system is isolated from
the immune system. However, recent studies have highlighted the borders of the central …

The field of autoimmune neurology is rapidly evolving, and recent discoveries have
advanced our understanding of disease aetiologies. In this article, we review the key …

The CNS is protected by the immune system, including cells that reside directly within the
CNS and help to ensure proper neural function, as well as cells that traffic into the CNS with …

Because of the compartmentalization of disciplines that shaped the academic landscape of
biology and biomedical sciences in the past, physiological systems have long been studied …

Neuroimmunology is one of the fastest-growing fields in the life sciences, and for good
reason; it fills the gap between two principal systems of the organism, the nervous system …

The meninges, comprising the leptomeninges (pia and arachnoid layers) and the
pachymeninx (dura layer), participate in central nervous system (CNS) autoimmunity, but …

Immune dysfunction is commonly associated with several neurological and mental
disorders. Although the mechanisms by which peripheral immunity may influence neuronal …

Meningeal lymphatics near the cribriform plate undergo lymphangiogenesis during
neuroinflammation to drain excess fluid. Here, we hypothesized that lymphangiogenic …

The brain and its borders create a highly dynamic microenvironment populated with immune
cells. Yet characterization of immune cells within the naive brain compartment remains …

Discoveries leading to an improved understanding of immune surveillance of the central
nervous system (CNS) have repeatedly provoked dismissal of the existence of immune …