SARS-CoV-2 is the causative agent of the COVID-19 pandemic, with 10 million infections
and more than 500,000 fatalities by June 2020. To initiate infection, the SARS-CoV-2 spike …

The worldwide pandemic caused by the severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) is unprecedented and the impact on public health and the global economy …

The coronavirus (CoV) spike (S) protein, involved in viral–host cell fusion, is the primary
immunogenic target for virus neutralization and the current focus of many vaccine design …

Various human pathogenic viruses employ envelope glycoproteins for host cell receptor
recognition and binding, membrane fusion and viral entry. The spike (S) glycoprotein of …

Current COVID-19 vaccines and many clinical diagnostics are based on the structure and
function of the SARS-CoV-2 spike ectodomain. Using hydrogen–deuterium exchange …

Coronavirus research has gained tremendous attention because of the COVID-19
pandemic, caused by the novel severe acute respiratory syndrome coronavirus (nCoV or …

The spike (S) protein of SARS-CoV-2 mediates receptor binding and cell entry and is the
dominant target of the immune system. It exhibits substantial conformational flexibility. It …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike glycoprotein is the
prime target for vaccines, diagnostics, and therapeutic antibodies against the virus. While …

Vaccine efforts to combat the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-
2), which is responsible for the current coronavirus disease 2019 (COVID-19) pandemic, are …

Intervention strategies are urgently needed to control the severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) pandemic. The trimeric viral spike (S) protein catalyzes fusion …