[HTML][HTML] Inactivation of the phospholipase B gene PLB5 in wild-type Candida albicans reduces cell-associated phospholipase A2 activity and attenuates virulence
S Theiss, G Ishdorj, A Brenot, M Kretschmar… - International Journal of …, 2006 - Elsevier
Phospholipases are critical for modification and redistribution of lipid substrates, membrane
remodeling and microbial virulence. Among the many different classes of phospholipases …
remodeling and microbial virulence. Among the many different classes of phospholipases …
[HTML][HTML] Cloning and disruption of caPLB1, a phospholipase B gene involved in the pathogenicity of Candida albicans
SD Leidich, AS Ibrahim, Y Fu, A Koul, C Jessup… - Journal of Biological …, 1998 - ASBMB
The Candida albicans PLB1gene was cloned using a polymerase chain reaction-based
approach relying on degenerate oligonucleotide primers designed according to the amino …
approach relying on degenerate oligonucleotide primers designed according to the amino …
Potential role of phospholipases in virulence and fungal pathogenesis
MA Ghannoum - Clinical microbiology reviews, 2000 - Am Soc Microbiol
Microbial pathogens use a number of genetic strategies to invade the host and cause
infection. These common themes are found throughout microbial systems. Secretion of …
infection. These common themes are found throughout microbial systems. Secretion of …
Reintroduction of the PLB1 gene into Candida albicans restores virulence in vivo
PK Mukherjee, KR Seshan, SD Leidich… - …, 2001 - microbiologyresearch.org
Phospholipases have been proposed to contribute to the virulence of Candida albicans.
Recently, a candidal strain deleted for PLB1, the gene encoding the predominant …
Recently, a candidal strain deleted for PLB1, the gene encoding the predominant …
Differential expression of Candida albicans phospholipase B (PLB1) under various environmental and physiological conditions
PK Mukherjee, J Chandra, DM Kuhn… - …, 2003 - microbiologyresearch.org
Candida is the fourth most common organism responsible for bloodstream infections in
many intensive care units, with Candida albicans being the most predominant species …
many intensive care units, with Candida albicans being the most predominant species …
Molecular cloning of a second phospholipase B gene, caPLB2 from Candida albicans
Y Sugiyama, S Nakashima, F Mirbod, H Kanoh… - …, 1999 - academic.oup.com
Accumulating evidence suggests that phospholipase B, secreted by pathogenic fungi such
as Candida albicans, Cryptococcus neoformans and Aspergillus fumigatus, functions as one …
as Candida albicans, Cryptococcus neoformans and Aspergillus fumigatus, functions as one …
Functional analysis of the phospholipase C gene CaPLC1 and two unusual phospholipase C genes, CaPLC2 and CaPLC3, of Candida albicans
D Kunze, I Melzer, D Bennett, D Sanglard… - …, 2005 - microbiologyresearch.org
Phospholipases C are known to be important regulators of cellular processes but may also
act as virulence factors of pathogenic microbes. At least three genes in the genome of the …
act as virulence factors of pathogenic microbes. At least three genes in the genome of the …
Phospholipase B enzyme expression is not associated with other virulence attributes in Candida albicans isolates from patients with human immunodeficiency virus …
YH Samaranayake… - Journal of Medical …, 2005 - microbiologyresearch.org
The extracellular phospholipases of Candida albicans are considered to play a significant
role in the pathogenesis of human infections. Therefore 30 clinical isolates of C. albicans …
role in the pathogenesis of human infections. Therefore 30 clinical isolates of C. albicans …
Candida albicans PLD1 activity is required for full virulence
JW Dolan, AC Bell, B Hube, M Schaller… - Medical …, 2004 - Taylor & Francis
Phospholipase D1 (PLD1) mutants of Candida albicans are defective in important in vivo
and in vitro virulence factors. PLD1 mutants colonize the murine alimentary tract as well as …
and in vitro virulence factors. PLD1 mutants colonize the murine alimentary tract as well as …
Extracellular phospholipases as universal virulence factor in pathogenic fungi
MA Ghannoum - Nippon Ishinkin Gakkai Zasshi, 1998 - jstage.jst.go.jp
Microbial pathogens use a number of genetic strategies to invade the host and cause
infection. These common themes are found throughout microbial virulence factors. Secretion …
infection. These common themes are found throughout microbial virulence factors. Secretion …