Phospholipases are critical for modification and redistribution of lipid substrates, membrane
remodeling and microbial virulence. Among the many different classes of phospholipases …

The Candida albicans PLB1gene was cloned using a polymerase chain reaction-based
approach relying on degenerate oligonucleotide primers designed according to the amino …

Microbial pathogens use a number of genetic strategies to invade the host and cause
infection. These common themes are found throughout microbial systems. Secretion of …

Phospholipases have been proposed to contribute to the virulence of Candida albicans.
Recently, a candidal strain deleted for PLB1, the gene encoding the predominant …

Candida is the fourth most common organism responsible for bloodstream infections in
many intensive care units, with Candida albicans being the most predominant species …

Accumulating evidence suggests that phospholipase B, secreted by pathogenic fungi such
as Candida albicans, Cryptococcus neoformans and Aspergillus fumigatus, functions as one …

Phospholipases C are known to be important regulators of cellular processes but may also
act as virulence factors of pathogenic microbes. At least three genes in the genome of the …

The extracellular phospholipases of Candida albicans are considered to play a significant
role in the pathogenesis of human infections. Therefore 30 clinical isolates of C. albicans …

Phospholipase D1 (PLD1) mutants of Candida albicans are defective in important in vivo
and in vitro virulence factors. PLD1 mutants colonize the murine alimentary tract as well as …

Microbial pathogens use a number of genetic strategies to invade the host and cause
infection. These common themes are found throughout microbial virulence factors. Secretion …