[PDF][PDF] Pharmacological characterization of LY303870: a novel, potent and selective nonpeptide substance P (neurokinin-1) receptor antagonist.
BD Gitter, RF Bruns, JJ Howbert… - … of Pharmacology and …, 1995 - researchgate.net
ABSTRACT LY303870[(R)-1-[N-(2-methoxybenzyl) acetylamino]-3-(1 H-in-dol-3-yl)-2-[N-(2-
(4-(piperidin-1-yI) piperidin-l-yI) acetyl) amino]-propane] is a new, potent and selective …
(4-(piperidin-1-yI) piperidin-l-yI) acetyl) amino]-propane] is a new, potent and selective …
[PDF][PDF] Characterization of CP-122,721; a nonpeptide antagonist of the neurokinin NK1 receptor.
S McLean, A Ganong, PA Seymour, DK Bryce… - … of Pharmacology and …, 1996 - Citeseer
ABSTRACT CP-1 22,721[(+)-(2S, 3S)-3-(2-methoxy-5-tnfluoromethoxyben-zyl) amino-2-
phenylpiperidinej interacts with high affinity (plC50= 9.8) at the human NK1 receptor …
phenylpiperidinej interacts with high affinity (plC50= 9.8) at the human NK1 receptor …
LY303870, a centrally active neurokinin-1 antagonist with a long duration of action
S Iyengar, PA Hipskind, DR Gehlert, D Schober… - … of Pharmacology and …, 1997 - ASPET
The selective neurokinin (NK)-1 antagonist LY303870 has high affinity and specificity for
human and guinea pig brain NK-1 receptors labeled with 125I-substance P. It has …
human and guinea pig brain NK-1 receptors labeled with 125I-substance P. It has …
Characterization of the interaction of diacylpiperazine antagonists with the human neurokinin-1 receptor: identification of a common binding site for structurally …
MA Cascieri, LL Shiao, SG Mills, M MacCoss… - Molecular …, 1995 - ASPET
We recently described a novel series of diacylpiperazine antagonists of the human
neurokinin (NK)-1 receptor. The diacylpiperazine compounds are structurally dissimilar from …
neurokinin (NK)-1 receptor. The diacylpiperazine compounds are structurally dissimilar from …
In vitro and in vivo characterization of MDL 105,212 A, a nonpeptide NK-1/NK-2 tachykinin receptor antagonist.
EM Kudlacz, SA Shatzer, RW Knippenberg… - … of Pharmacology and …, 1996 - ASPET
We have identified and characterized a novel, potent, nonselective tachykinin receptor
antagonist, MDL 105,212 A [(R)-1-[2-[3-(3, 4-dichlorophenyl)-1-(3, 4, 5-trimethoxybenzoyl) …
antagonist, MDL 105,212 A [(R)-1-[2-[3-(3, 4-dichlorophenyl)-1-(3, 4, 5-trimethoxybenzoyl) …
Characterization of the binding of [125I-iodo-histidyl, methyl-Phe7] neurokinin B to the neurokinin-3 receptor
S Sadowski, RRC Huang, TM Fong, O Marko… - Neuropeptides, 1993 - Elsevier
We have characterized the binding of [125 I-iodo-histidyl, methyl Phe 7] neurokinin B (125 I-
NKB) to the human neurokinin-3 (NK3) receptor. 125 I-NKB specifically binds to the NK3 …
NKB) to the human neurokinin-3 (NK3) receptor. 125 I-NKB specifically binds to the NK3 …
Comparative, general pharmacology of SDZ NKT 343, a novel, selective NK1 receptor antagonist
CSJ Walpole, MCS Brown, IF James… - British journal of …, 1998 - Wiley Online Library
The in vitro and in vivo pharmacology of SDZ NKT 343 (2‐nitrophenyl‐carbamoyl‐(S)‐prolyl‐
(S)‐3‐(2‐naphthyl) alanyl‐N‐benzyl‐N‐methylamide), a novel tachykinin NK1 receptor …
(S)‐3‐(2‐naphthyl) alanyl‐N‐benzyl‐N‐methylamide), a novel tachykinin NK1 receptor …
SSR240600 [(R)-2-(1-{2-[4-{2-[3, 5-Bis (trifluoromethyl) phenyl] acetyl}-2-(3, 4-dichlorophenyl)-2-morpholinyl] ethyl}-4-piperidinyl)-2-methylpropanamide], a Centrally …
X Emonds-Alt, V Proietto, R Steinberg… - … of Pharmacology and …, 2002 - ASPET
The biochemical and pharmacological properties of a novel antagonist of the tachykinin
neurokinin 1 (NK1) receptor, SSR240600 [(R)-2-(1-{2-[4-{2-[3, 5-bis (trifluoromethyl) phenyl] …
neurokinin 1 (NK1) receptor, SSR240600 [(R)-2-(1-{2-[4-{2-[3, 5-bis (trifluoromethyl) phenyl] …
Functional characterization of the nonpeptide neurokinin3 (NK3) receptor antagonist, SR142801 on the human NK3 receptor expressed in Chinese hamster ovary …
F Oury-Donat, P Carayon, O Thurneyssen… - … of Pharmacology and …, 1995 - ASPET
The effects of SR142801, a nonpeptide tachykinin neurokinin (NK3) receptor antagonist,
were investigated on the functional events linked to NK3 receptor activation by using …
were investigated on the functional events linked to NK3 receptor activation by using …
Pharmacological Characterization of T-2328, 2-Fluoro-4'-methoxy-3'-[[[(2S, 3S)-2-phenyl-3-piperidinyl] amino] methyl]-[1, 1'-biphenyl]-4-carbonitrile Dihydrochloride …
Y Watanabe, H Asai, T Ishii, S Kiuchi… - Journal of …, 2008 - Elsevier
The pharmacological properties of T-2328 were evaluated as an antagonist of the tachykinin
neurokinin 1 (NK 1) receptor. T-2328 inhibited the specific binding of [3 H][Sar 9, Met (O 2) …
neurokinin 1 (NK 1) receptor. T-2328 inhibited the specific binding of [3 H][Sar 9, Met (O 2) …