La especie humana se ve gravemente afectada por la enfermedad de la malaria, que es
una infección parasitaria causada por cinco especies distintas de Plasmodium, de las …

There is high importance for the control of parasite Plasmodium falciparum which is
responsible for causing malaria. Following the classical mevalonate pathway, the metabolite …

Plasmodium falciparum 1-deoxy-D-xylulose-5-phosphate reductoisomerase (PfDXR) is a
key enzyme in the synthesis of isoprenoids in the malaria parasite, using a pathway that is …

The methyl erythritol phosphate (MEP) pathway of isoprenoid biosynthesis is essential for
malaria parasites and also for several human pathogenic bacteria, thus representing an …

Novel antimalarial drugs are urgently needed to treat severe malaria caused by Plasmodium
falciparum. Isoprenoid biosynthesis is a promising target pathway, since the biosynthetic …

The MEP (Methyl Erythritol Phosphate) isoprenoids biosynthesis pathway is an attractive
drug target to combat malaria, due to its uniqueness and indispensability for the parasite. It …

The apicoplast is an essential plastid organelle found in Plasmodium parasites which
contains several clinically validated antimalarial-drug targets. A chemical rescue screen …

1-Deoxy-d-xylulose 5-phosphate reductoisomerase of Plasmodium falciparum (Pf IspC, Pf
Dxr), believed to be the rate-limiting enzyme of the nonmevalonate pathway of isoprenoid …

The non-mevalonate (methylerythritol phosphate, MEP) pathway for isoprenoid biosynthesis
is essential in Plasmodium spp.., but is absent in the human host. The pathway is a clinically …

In Plasmodium falciparum, the formation of isopentenyl diphosphate and dimethylallyl
diphosphate, central intermediates in the biosynthesis of isoprenoids, occurs via the …