The glycosaminoglycans (GAGs) heparan sulfate, dermatan sulfate, and heparin are
important anticoagulants that inhibit clot formation through interactions with antithrombin and …

Glycosaminoglycans (GAGs) are widely distributed in animal tissues where they are usually
associated with proteins. Six types are commonly recognized: heparin (Hep), heparan …

Heparin, the widely used pharmaceutical anticoagulant, has been in clinical use for well
over half a century. Its introduction reduced clotting risks substantially and subsequent …

Members of the serine protease inhibitor (serpin) superfamily play important roles in the
inhibition of serine proteases involved in complex systems. This is evident in the regulation …

Serpins are the predominant protease inhibitors in the higher organisms and are
responsible, in humans, for the control of many highly regulated processes including blood …

We investigated the mechanisms of anticoagulant activity mediated by sulfated galactans.
The anticoagulant activity of sulfated polysaccharides is achieved mainly through …

Heparin and HS are glycosaminoglycans (GAGS), and are synthesized as proteoglycans in
which the GAG chains are covalently bound to serine residues of core proteins. GAGS are …

Clot-bound thrombin proteolyses fibrinogen and amplifies the coagulation cascade at its
close vicinity, thereby ensuring the growth of fibrin-rich thrombus. The present study …

The binding of heparin to human monocytes and the monocytoid cell line U937 was
characterized. Heparin binding was rapid, specific, saturable, and reversible. There was a …

The anticoagulant activities of glycosaminoglycans are mediated by antithrombin III (ATIII)
and heparin cofactor II (HCII), members of the “serpin” family that are present in plasma at …