Nrf2 and heme oxygenase-1 involvement in atherosclerosis related oxidative stress

JA Alonso-Piñeiro, A Gonzalez-Rovira… - Antioxidants, 2021 - mdpi.com
Atherosclerosis remains the underlying process responsible for cardiovascular diseases
and the high mortality rates associated. This chronic inflammatory disease progresses with …

Heme oxygenase-1, oxidation, inflammation, and atherosclerosis

JA Araujo, M Zhang, F Yin - Frontiers in pharmacology, 2012 - frontiersin.org
Atherosclerosis is an inflammatory process of the vascular wall characterized by the
infiltration of lipids and inflammatory cells. Oxidative modifications of infiltrating low-density …

Activation of Nrf2/HO-1 pathway and human atherosclerotic plaque vulnerability: an in vitro and in vivo study

S Fiorelli, B Porro, N Cosentino, A Di Minno… - Cells, 2019 - mdpi.com
Reactive oxygen species (ROS) induce nuclear factor erythroid 2–related factor 2 (Nrf2)
activation as an adaptive defense mechanism, determining the synthesis of antioxidant …

Oxidative stress in cardiovascular diseases: involvement of Nrf2 antioxidant redox signaling in macrophage foam cells formation

BK Ooi, BH Goh, WH Yap - International journal of molecular sciences, 2017 - mdpi.com
Oxidative stress is an important risk factor contributing to the pathogenesis of cardiovascular
diseases. Oxidative stress that results from excessive reactive oxygen species (ROS) …

Role of Nrf2 in the pathogenesis of atherosclerosis

J Mimura, K Itoh - Free Radical Biology and Medicine, 2015 - Elsevier
Atherosclerosis is a chronic inflammatory disease of the vascular arterial walls. A number of
studies have revealed the biological and genetic bases of atherosclerosis, and over 100 …

Nrf2 as a potential mediator of cardiovascular risk in metabolic diseases

RM da Costa, D Rodrigues, CA Pereira… - Frontiers in …, 2019 - frontiersin.org
Free radicals act as secondary messengers, modulating a number of important biological
processes, including gene expression, ion mobilization in transport systems, protein …

[PDF][PDF] The role of Nrf2 in oxidative stress-induced endothelial injuries

B Chen, Y Lu, Y Chen, J Cheng - J Endocrinol, 2015 - scholar.archive.org
Endothelial dysfunction is an important risk factor for cardiovascular disease, and it
represents the initial step in the pathogenesis of atherosclerosis. Failure to protect against …

[PDF][PDF] Nrf2/ARE regulated antioxidant gene expression in endothelial and smooth muscle cells in oxidative stress: implications for atherosclerosis and preeclampsia

GE Mann, J Niehueser-Saran, A Watson… - ACTA …, 2007 - researchgate.net
Increased generation of reactive oxygen species (ROS) in vascular diseases such as
atherosclerosis, diabetes, chronic renal failure and preeclampsia readily leads to impaired …

The role of the Nrf2/ARE antioxidant system in preventing cardiovascular diseases

RE Smith, K Tran, CC Smith, M McDonald… - Diseases, 2016 - mdpi.com
It is widely believed that consuming foods and beverages that have high concentrations of
antioxidants can prevent cardiovascular diseases and many types of cancer. As a result …

Nuclear factor (erythroid-derived 2)-like-2 factor (Nrf2), a key regulator of the antioxidant response to protect against atherosclerosis and nonalcoholic steatohepatitis

AA Gupte, CJ Lyon, WA Hsueh - Current diabetes reports, 2013 - Springer
Tissue oxidative stress is a common hallmark of atherosclerosis and non-alcoholic
steatohepatitis (NASH), 2 conditions linked epidemiologically and pathophysiologically …