Although substantial evidence has established that microglia and astrocytes play a key role
in the establishment and maintenance of persistent pain in animal models, the role of glial …

We recently showed that patients with different chronic pain conditions (such as chronic low
back pain, fibromyalgia, migraine and Gulf War illness) demonstrated elevated brain and/or …

At present, effective drug for treatment of neuropathic pain is still lacking. Recent studies
have shown that the ligands of translocator protein (TSPO, 18 kDa), a peripheral receptor for …

Pain is a sensation we have all experienced. For most of us, the pain has been temporary.
However, for patients with pathological pain, the pain experience is unending, with little …

This study investigated whether the second-generation translocator protein 18kDa (TSPO)
radioligand,[18F]-FEPPA, could be used in neurodegenerative parkinsonian disorders as a …

Tissue or nerve injury induces widespread plastic changes from the periphery and spinal
cord up to the cortex, resulting in chronic pain. Although many clinicians and researchers …

Cognitive self-regulation can strongly modulate pain and emotion. However, it is unclear
whether self-regulation primarily influences primary nociceptive and affective processes or …

The emerging literature implicates a role for glia/cytokines in persistent pain. However, the
mechanisms by which these non-neural elements contribute to CNS activity-dependent …

Chronic pain and anxiety symptoms are frequently encountered clinically, but the neural
circuit mechanisms underlying the comorbid anxiety symptoms in pain (CASP) in context of …

This review examines recently recognized roles of immunological processes in pain
modulation and explores the potential implications of these immunologically derived …