Low-Dose Interferon I and III-Based Nasal Sprays: A Good-Looking COVID-19 Vaccine Candidate and a Therapy of the Future?

TN Carp, M Metoudi, B Brown, V Ojha - 2023 - preprints.org
The SARS–CoV-2 infection has caused both acute and chronic COVID–19 disease during
the recent pandemic with emerging more transmissible SARS–CoV–2 Omicron variants …

Development and challenges of nasal spray vaccines for short-term COVID-19 protection

J Xi - Current Pharmaceutical Biotechnology, 2022 - ingentaconnect.com
For those who have traveled by flight during this pandemic and been seated in a packed
cabin for an extended period, it is natural to worry about the elevated risk of COVID-19 …

[HTML][HTML] Mucosal immunity: The missing link in comprehending SARS-CoV-2 infection and transmission

MW Russell, J Mestecky - Frontiers in immunology, 2022 - frontiersin.org
SARS-CoV-2 is primarily an airborne infection of the upper respiratory tract, which on
reaching the lungs causes the severe acute respiratory disease, COVID-19. Its first contact …

[PDF][PDF] Ahead of a vaccine: A safe method of protection against COVID-19 exists

K Alibek, A Tskhay - Research Ideas and Outcomes, 2020 - riojournal.com
In the case of current COVID-19, successful prophylactic approaches are likely to have a
greater impact than successful treatment approaches. In this article, we discuss the …

Non-adjuvanted interferon-armed RBD protein nasal drops protect airway infection from SARS-CoV-2

Y Lin, J Sun, X Cao, X Wang, X Chen, H Xu, J Zhao… - Cell Discovery, 2022 - nature.com
Dear Editor, The COVID-19 pandemic caused by SARS-CoV-2, highly transmissible from
person to person via droplets and small particles inhaled in the upper respiratory tract, leads …

[PDF][PDF] Nasally delivered interferon-λ protects mice against infection by SARS-CoV-2 variants including Omicron

Z Chong, CE Karl, PJ Halfmann, Y Kawaoka… - Cell reports, 2022 - cell.com
Although vaccines and monoclonal antibody countermeasures have reduced the morbidity
and mortality associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV …

Intranasal vaccines for SARS-CoV-2: From challenges to potential in COVID-19 management

VP Chavda, LK Vora, AK Pandya, VB Patravale - Drug discovery today, 2021 - Elsevier
Abstract Unlike conventional Coronavirus 2019 (COVID-19) vaccines, intranasal vaccines
display a superior advantage because the nasal mucosa is often the initial site of infection …

[HTML][HTML] Nasally-delivered interferon-λ protects mice against upper and lower respiratory tract infection of SARS-CoV-2 variants including Omicron

Z Chong, CE Karl, PJ Halfmann, Y Kawaoka… - bioRxiv, 2022 - ncbi.nlm.nih.gov
Although vaccines and monoclonal antibody countermeasures have reduced the morbidity
and mortality associated with SARS-CoV-2 infection, variants with constellations of …

[HTML][HTML] Dealing with a mucosal viral pandemic: lessons from COVID-19 vaccines

V Mouro, A Fischer - Mucosal immunology, 2022 - Elsevier
The development and deployment of vaccines against COVID-19 demonstrated major
successes in providing immunity and preventing severe disease and death. Yet SARS-CoV …

Pharmacodynamic of Recombinant Human Interferon Alpha-2b Nasal Drops and Effective Prophylaxis Against SARS-COV-2 Infection

H Nodarse-Cuni, O Bravo, R Cañete… - Journal of Interferon & …, 2024 - liebertpub.com
The recombinant human interferon alpha-2b (IFN-a2b) nasal drop formulation (Nasalferon)
was studied as prophylaxis for SARS-CoV-2. Healthy volunteers between 19 and 80 years …