Fasting and cancer: molecular mechanisms and clinical application

A Nencioni, I Caffa, S Cortellino, VD Longo - Nature Reviews Cancer, 2018 - nature.com
The vulnerability of cancer cells to nutrient deprivation and their dependency on specific
metabolites are emerging hallmarks of cancer. Fasting or fasting-mimicking diets (FMDs) …

Fasting and caloric restriction in cancer prevention and treatment

S Brandhorst, VD Longo - Metabolism in cancer, 2016 - Springer
Cancer is the second leading cause of death in the USA and among the leading major
diseases in the world. It is anticipated to continue to increase because of the growth of the …

A review of fasting effects on the response of cancer to chemotherapy

M Sadeghian, S Rahmani, S Khalesi, E Hejazi - Clinical nutrition, 2021 - Elsevier
Background & aims Studies suggest that fasting before or during chemotherapy may induce
differential stress resistance, reducing the adverse effects of chemotherapy and enhancing …

Fasting vs dietary restriction in cellular protection and cancer treatment: from model organisms to patients

C Lee, VD Longo - Oncogene, 2011 - nature.com
The dietary recommendation for cancer patients receiving chemotherapy, as described by
the American Cancer Society, is to increase calorie and protein intake. Yet, in simple …

[HTML][HTML] Exceptional tumour responses to fasting-mimicking diet combined with standard anticancer therapies: a sub-analysis of the NCT03340935 trial

F Ligorio, G Fucà, L Provenzano, R Lobefaro… - European Journal of …, 2022 - Elsevier
Background Cyclic fasting or calorie-restricted, low-carbohydrate, low-protein diets,
collectively referred to as fasting-mimicking diets (FMDs), demonstrated additive or …

Fasting-mimicking diet is safe and reshapes metabolism and antitumor immunity in patients with cancer

C Vernieri, G Fucà, F Ligorio, V Huber, A Vingiani… - Cancer Discovery, 2022 - AACR
In tumor-bearing mice, cyclic fasting or fasting-mimicking diets (FMD) enhance the activity of
antineoplastic treatments by modulating systemic metabolism and boosting antitumor …

Fasting and fasting mimicking diets in cancer prevention and therapy

O Blaževitš, M Di Tano, VD Longo - Trends in Cancer, 2023 - cell.com
Fasting mimicking diets (FMDs) are emerging as effective dietary interventions with the
potential to improve healthspan and decrease the incidence of cancer and other age-related …

Fasting-mimicking diet synergizes with ferroptosis against quiescent, chemotherapy-resistant cells

X Liu, S Peng, G Tang, G Xu, Y Xie, D Shen, M Zhu… - …, 2023 - thelancet.com
Background More than ten randomized clinical trials are being tested to evaluate the
efficacy, effectiveness and safety of a fasting-mimicking diet (FMD) combined with different …

Safety and feasibility of fasting-mimicking diet and effects on nutritional status and circulating metabolic and inflammatory factors in cancer patients undergoing active …

F Valdemarin, I Caffa, A Persia, AL Cremonini… - Cancers, 2021 - mdpi.com
Simple Summary Our phase I/II clinical trial demonstrated that periodic cycles of a modified
fasting regime (“fasting-mimicking diet”(FMD) by L-Nutra) were feasible and safe in cancer …

Effects of short-term fasting on cancer treatment

S de Groot, H Pijl, JJM van der Hoeven… - Journal of Experimental & …, 2019 - Springer
Growing preclinical evidence shows that short-term fasting (STF) protects from toxicity while
enhancing the efficacy of a variety of chemotherapeutic agents in the treatment of various …