[HTML][HTML] Cardiovascular and renal outcomes with SGLT2 inhibitors: real-life observational studies in older patients with type 2 diabetes: SGLT2 inhibitors in elderly and …

AJ Scheen - Diabetes Epidemiology and Management, 2023 - Elsevier
Patients with type 2 diabetes mellitus (T2DM) are exposed to a high risk of atherosclerotic
cardiovascular disease, heart failure and chronic kidney disease. The incidence of these …

Efficacy and safety profile of SGLT2 inhibitors in the elderly: How is the benefit/risk balance?

AJ Scheen, F Bonnet - Diabetes & Metabolism, 2023 - Elsevier
Type 2 diabetes mellitus (T2DM) is a highly prevalent health condition in the aging
population. Older adults with T2DM have higher risks of cardiovascular disease, heart failure …

Safety of sodium‐glucose cotransporter 2 inhibitors in elderly patients with type 2 diabetes: A meta‐analysis of randomized controlled trials

M Rigato, GP Fadini, A Avogaro - Diabetes, Obesity and …, 2023 - Wiley Online Library
Aim Sodium‐glucose cotransporter 2 inhibitors (SGLT2is) are particularly effective in
preventing adverse outcomes of heart failure and chronic kidney disease, which are highly …

Long‐term safety and efficacy of SGLT2 inhibitor use in older east Asians with type 2 diabetes

Y Takahashi, Y Seino, D Yabe - Journal of Diabetes …, 2024 - Wiley Online Library
Sodium‐glucose cotransporter 2 inhibitors (SGLT2is) have been shown in cardiovascular
outcome trials to reduce the risk of heart failure and major adverse cardiovascular as well as …

[HTML][HTML] Real-life underuse of SGLT2 inhibitors for patients with type 2 diabetes at high cardiorenal risk

AJ Scheen - Diabetes Epidemiology and Management, 2023 - Elsevier
Atherosclerotic cardiovascular disease (ASCVD), heart failure (HF) and chronic kidney
disease (CKD) are major complications of type 2 diabetes (T2DM). The objectives of …

Sodium-glucose cotransporter-2 inhibitors (SGLT2) in frail or older people with type 2 diabetes and heart failure: a systematic review and meta-analysis

R Aldafas, T Crabtree, M Alkharaiji… - Age and …, 2024 - academic.oup.com
Objective Sodium-glucose cotransporter-2 inhibitors (SGLT2Is) reduce cardio-metabolic and
renal outcomes in patients with type 2 diabetes (T2D) but their efficacy and safety in older or …

[HTML][HTML] Cardiorenal impact of SGLT-2 inhibitors: A conceptual revolution in the management of type 2 diabetes, heart failure and chronic kidney disease

R Nevola, M Alfano, PC Pafundi, C Brin… - Reviews in …, 2022 - imrpress.com
Type 2 Diabetes Mellitus (T2DM) is associated with an elevated incidence of cardiovascular
and renal diseases, responsible for mortality rates significantly higher than in the general …

[HTML][HTML] Cardiovascular and renal benefits of SGLT2 inhibitors: a narrative review

S Rabizadeh, M Nakhjavani… - International journal of …, 2019 - ncbi.nlm.nih.gov
Results Cardiovascular disease represents a large health burden in patients with diabetes.
The prevention of cardiovascular events is a major concern in the treatment of patients with …

Kidney and cardiovascular protection with SGLT2 inhibitors: lessons from cardiovascular outcome trials and CREDENCE

DV O'Hara, BL Neuen, MJ Jardine - Journal of Nephrology, 2020 - Springer
The burden of diabetic kidney disease is rising rapidly worldwide, and new therapies are of
vital importance to reduce the risk of kidney failure and major cardiovascular events. Of the …

SGLT-2 inhibitors as cardio-renal protective agents

I Caruso, F Giorgino - Metabolism, 2022 - Elsevier
Despite remarkable advances in diabetes care, patients with type 2 diabetes are still
burdened by higher morbidity and mortality than non-diabetic individuals. Atherosclerotic …