[HTML][HTML] Dietary (n-3) polyunsaturated fatty acids remodel mouse T-cell lipid rafts
YY Fan, DN McMurray, LH Ly, RS Chapkin - The Journal of nutrition, 2003 - Elsevier
In vitro evidence indicates that (n-3) polyunsaturated fatty acids (PUFA) suppress T-cell
activation in part by displacing proteins from lipid rafts, specialized regions within the plasma …
activation in part by displacing proteins from lipid rafts, specialized regions within the plasma …
Dietary docosahexaenoic acid suppresses T cell protein kinase Cθ lipid raft recruitment and IL-2 production
YY Fan, LH Ly, R Barhoumi, DN McMurray… - The Journal of …, 2004 - journals.aai.org
To date, the proximal molecular targets through which dietary n-3 polyunsaturated fatty acids
(PUFA) suppress the inflammatory process have not been elucidated. Because cholesterol …
(PUFA) suppress the inflammatory process have not been elucidated. Because cholesterol …
Remodelling of primary human CD4+ T cell plasma membrane order by n-3 PUFA
Cell membrane fatty acids influence fundamental properties of the plasma membrane,
including membrane fluidity, protein functionality, and lipid raft signalling. Evidence suggests …
including membrane fluidity, protein functionality, and lipid raft signalling. Evidence suggests …
Regulatory activity of polyunsaturated fatty acids in T-cell signaling
n− 3 Polyunsaturated fatty acids (PUFA) are considered to be authentic immunosuppressors
and appear to exert beneficial effects with respect to certain immune-mediated diseases. In …
and appear to exert beneficial effects with respect to certain immune-mediated diseases. In …
Polyunsaturated eicosapentaenoic acid displaces proteins from membrane rafts by altering raft lipid composition
TM Stulnig, J Huber, N Leitinger, EM Imre… - Journal of Biological …, 2001 - ASBMB
Polyunsaturated fatty acids (PUFAs) such as eicosapentaenoic acid (20: 5 (n-3)) inhibit T
lymphocyte activation probably by displacing acylated signaling proteins from membrane …
lymphocyte activation probably by displacing acylated signaling proteins from membrane …
LAT displacement from lipid rafts as a molecular mechanism for the inhibition of T cell signaling by polyunsaturated fatty acids
M Zeyda, G Staffler, V Hořejšı́, W Waldhäusl… - Journal of Biological …, 2002 - ASBMB
Polyunsaturated fatty acids (PUFAs) suppress immune responses and inhibit T cell
activation through largely unknown mechanisms. The displacement of signaling proteins …
activation through largely unknown mechanisms. The displacement of signaling proteins …
Docosahexaenoic acid changes lipid composition and interleukin-2 receptor signaling in membrane rafts
Q Li, M Wang, L Tan, C Wang, J Ma, N Li, Y Li… - Journal of lipid …, 2005 - ASBMB
Polyunsaturated fatty acids, including docosahexaenoic acid (DHA, 22: 6n-3), modulate
immune responses and exert beneficial immunosuppressive effects, but the molecular …
immune responses and exert beneficial immunosuppressive effects, but the molecular …
Polyunsaturated eicosapentaenoic acid changes lipid composition in lipid rafts
Q Li, L Tan, C Wang, N Li, Y Li, G Xu, J Li - European journal of nutrition, 2006 - Springer
Summary Background Polyunsaturated fatty acids (PUFAs) modulate immune responses
particularly by affecting T cell function and are applied clinically as adjuvant …
particularly by affecting T cell function and are applied clinically as adjuvant …
Polyunsaturated fatty acids inhibit T cell signal transduction by modification of detergent-insoluble membrane domains
TM Stulnig, M Berger, T Sigmund… - The Journal of cell …, 1998 - rupress.org
Polyunsaturated fatty acids (PUFAs) exert immunosuppressive effects, but the molecular
alterations leading to T cell inhibition are not yet elucidated. Signal transduction seems to …
alterations leading to T cell inhibition are not yet elucidated. Signal transduction seems to …
[HTML][HTML] Docosahexaenoic acid alters the size and distribution of cell surface microdomains
RS Chapkin, N Wang, YY Fan, JR Lupton… - Biochimica et Biophysica …, 2008 - Elsevier
We recently generated nutritional data suggesting that chemoprotective dietary n-3
polyunsaturated fatty acids (n-3 PUFA) are capable of displacing acylated proteins from lipid …
polyunsaturated fatty acids (n-3 PUFA) are capable of displacing acylated proteins from lipid …
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