Streptococcus pneumoniae (SPN) is a globally significant cause of meningitis, the
pathophysiology of which involves damage to the brain by both bacterial virulence factors …

Streptococcus pneumoniae is a major meningitis-causing pathogen globally, bringing about
significant morbidity and mortality, as well as long-term neurological sequelae in almost half …

Streptococcus pneumoniae (the pneumococcus) is the major cause of bacterial meningitis.
The mechanisms by which pneumococci from the bloodstream penetrate the blood–brain …

Meningitis, the inflammation of the protective membrane surrounding the brain and spinal
cord (known as meninges), is a condition associated with high mortality rates and …

Bacterial meningitis is an inflammatory disease of the meninges of the central nervous
system (CNS). Streptococcus pneumoniae (S. pneumoniae), Neisseria meningitidis, and …

Streptococcus pneumoniae (the pneumococcus) is a Gram-positive bacterium and the
predominant cause of bacterial meningitis. Meningitis is thought to occur as the result of …

Streptococcus pneumoniae (SPN), the leading cause of meningitis in children and adults
worldwide, is associated with an overwhelming host inflammatory response and subsequent …

The interactions between pneumoccocal surface components and host defence systems that
initiate pneumoccocal meningitis have been studied in considerable molecular detail over …

The blood–brain barrier, which is one of the tightest barriers in the body, protects the brain
from insults, such as infections. Indeed, only a few of the numerous blood-borne bacteria …

Bacterial meningitis is a devastating disease occurring worldwide with up to half of the
survivors left with permanent neurological sequelae. Due to intrinsic properties of the …