Objectives Tuberculosis is a chronic lung disease caused by Mycobacterium tuberculosis
(MTB), whose thick cell envelope and drug metabolizing enzymes offering it multidrug …

Incidences of drug-resistant tuberculosis have become common and are rising at an
alarming rate. Aminoacyl t-RNA synthetase has been validated as a newer target against …

Tuberculosis is a serious infectious disease caused by human pathogen bacteria
Mycobacterium tuberculosis. Bacterial drug resistance is a very significant medical problem …

Aminoacyl tRNA synthetases are novel antibacterial drug target because of their important
role in protein synthesis. In this study, we performed high throughput virtual screening of …

Despite the recent progress in the diagnosis of tuberculosis (TB), the chemotherapeutic
management of TB continues to be challenging. Mycobacterium tuberculosis (Mtb), the …

Background: The most serious challenge in the treatment of tuberculosis is the multidrug
resistance of Mycobacterium tuberculosis to existing antibiotics. As a strategy to overcome …

Human African trypanosomiasis (HAT), caused by the protozoan parasite Trypanosoma
brucei, is a neglected fatal disease. Leucyl-tRNA synthetase (LeuRS), which has been …

Background: The increasing incidence of multidrug-resistant cases of tuberculosis (TB) and
difficulty in treating these cases requires an urgent need to find an effective anti-TB drug …

Tuberculosis (TB) is caused by Mycobacterium tuberculosis (MTB), a highly infectious
disease accounting for nearly 1.5 million deaths every year and has been a major global …

Abstract DXR (1-deoxy-d-xylulose-5-phosphate reductoisomerase) is an essential enzyme
in the Methylerythritol 4-phosphate (MEP) pathway, which is used by M. tuberculosis and a …