Background Nuclear factor erythroid 2-related factor 2 (Nrf2) is a classical nuclear
transcription factor that regulates the system's anti-oxidative stress response. The activation …

Neurodegenerative disorders are characterized by progressive loss of neurons. To date, no
efficacious therapies exist for these disorders, and current therapies provide only …

Neurodegenerative diseases (NDs) affect the West due to the increase in life expectancy.
Nervous cells accumulate oxidative damage, which is one of the factors that triggers and …

Redox balance is essential to maintain the body's normal metabolism. Once disrupted, it
may lead to various chronic diseases, such as diabetes, neurodegenerative diseases …

Covering: 2000 to 2013 Oxidative stress is the central component of chronic diseases. The
nuclear factor erythroid 2-related factor 2/antioxidant response element (Nrf2/ARE) pathway …

The nuclear factor erythroid-derived 2-related factor 2 (NFE2L2/NRF2) is a master
transcription factor that regulates oxidative stress-related genes containing the antioxidant …

Clinical and preclinical research indicates that neurodegenerative diseases are
characterized by excess levels of oxidative stress (OS) biomarkers and by lower levels of …

Nuclear factor (erythroid‐derived 2)‐like 2 (Nrf2) is a basic‐region leucine zipper
transcription factor that regulates the expression of many Phase II detoxifying/antioxidant …

Increased reactive oxygen species production and oxidative stress have been implicated in
the pathogenesis of numerous neurodegenerative conditions including among others …

Traumatic brain injury (TBI), known as mechanical damage to the brain, impairs the normal
function of the brain seriously. Its clinical symptoms manifest as behavioral impairment …