Pathophysiology and treatment of type 2 diabetes: perspectives on the past, present, and future

SE Kahn, ME Cooper, S Del Prato - The Lancet, 2014 - thelancet.com
Glucose metabolism is normally regulated by a feedback loop including islet β cells and
insulin-sensitive tissues, in which tissue sensitivity to insulin affects magnitude of β-cell …

Type 2 diabetes: pathogenesis and treatment

M Stumvoll, BJ Goldstein, TW van Haeften - The Lancet, 2008 - thelancet.com
reliable than the much condemned impact factors for journals. 5–7 Also, related publications
will be easier to find once they are coded with a unique researcher identifier, not only from …

Management of type 2 diabetes: new and future developments in treatment

AA Tahrani, CJ Bailey, S Del Prato, AH Barnett - The Lancet, 2011 - thelancet.com
The increasing prevalence, variable pathogenesis, progressive natural history, and
complications of type 2 diabetes emphasise the urgent need for new treatment strategies …

Type 1 diabetes

MA Atkinson, GS Eisenbarth, AW Michels - The lancet, 2014 - thelancet.com
Over the past decade, knowledge of the pathogenesis and natural history of type 1 diabetes
has grown substantially, particularly with regard to disease prediction and heterogeneity …

Type 2 diabetes: principles of pathogenesis and therapy

M Stumvoll, BJ Goldstein, TW Van Haeften - The Lancet, 2005 - thelancet.com
Type 2 diabetes mellitus has become an epidemic, and virtually no physician is without
patients who have the disease. Whereas insulin insensitivity is an early phenomenon partly …

Type 1 diabetes

D Daneman - The Lancet, 2006 - thelancet.com
Type 1 diabetes accounts for only about 5–10% of all cases of diabetes; however, its
incidence continues to increase worldwide and it has serious short-term and long-term …

Prediabetes: a high-risk state for diabetes development

AG Tabák, C Herder, W Rathmann, EJ Brunner… - The Lancet, 2012 - thelancet.com
Prediabetes (intermediate hyperglycaemia) is a high-risk state for diabetes that is defined by
glycaemic variables that are higher than normal, but lower than diabetes thresholds. 5–10 …

Type 1 diabetes: new perspectives on disease pathogenesis and treatment

MA Atkinson, GS Eisenbarth - The Lancet, 2001 - thelancet.com
As our knowledge of type 1 (insulin-dependent) diabetes increases, so does our
appreciation for the pathogenic complexity of this disease and the challenges associated …

Type 1 diabetes

T Quattrin, LD Mastrandrea, LSK Walker - The Lancet, 2023 - thelancet.com
Type 1 diabetes is a chronic disease caused by autoimmune destruction of pancreatic β
cells. Individuals with type 1 diabetes are reliant on insulin for survival. Despite enhanced …

Understanding the mechanisms of reversal of type 2 diabetes

R Taylor, A Al-Mrabeh, N Sattar - The lancet Diabetes & …, 2019 - thelancet.com
Clinical and pathophysiological studies have shown type 2 diabetes to be a condition mainly
caused by excess, yet reversible, fat accumulation in the liver and pancreas. Within the liver …