[HTML][HTML] A molecular vision of fungal cell wall organization by functional genomics and solid-state NMR

A Chakraborty, LD Fernando, W Fang… - Nature …, 2021 - nature.com
Vast efforts have been devoted to the development of antifungal drugs targeting the cell wall,
but the supramolecular architecture of this carbohydrate-rich composite remains …

[HTML][HTML] Molecular architecture of fungal cell walls revealed by solid-state NMR

X Kang, A Kirui, A Muszyński, MCD Widanage… - Nature …, 2018 - nature.com
The high mortality of invasive fungal infections, and the limited number and inefficacy of
antifungals necessitate the development of new agents with novel mechanisms and targets …

Solid-state NMR molecular snapshots of Aspergillus fumigatus cell wall architecture during a conidial morphotype transition

G Lamon, A Lends, I Valsecchi… - Proceedings of the …, 2023 - National Acad Sciences
While establishing an invasive infection, the dormant conidia of Aspergillus fumigatus transit
through swollen and germinating stages, to form hyphae. During this morphotype transition …

Architecture of the dynamic fungal cell wall

NAR Gow, MD Lenardon - Nature Reviews Microbiology, 2023 - nature.com
The fungal cell wall is essential for growth and survival, and is a key target for antifungal
drugs and the immune system. The cell wall must be robust but flexible, protective and …

[HTML][HTML] Characterization of the cell wall of a mushroom forming fungus at atomic resolution using solid-state NMR spectroscopy

HL Ehren, FVW Appels, K Houben, MAM Renault… - The Cell Surface, 2020 - Elsevier
Cell walls are essential in the interaction of fungi with the (a) biotic environment and are also
key to hyphal morphogenesis and mechanical strength. Here, we used solid-state NMR …

The cell wall: a carbohydrate armour for the fungal cell

JP Latgé - Molecular microbiology, 2007 - Wiley Online Library
The cell wall is composed of a polysaccharide‐based three‐dimensional network.
Considered for a long time as an inert exoskeleton, the cell wall is now seen as a dynamic …

Aspergillus fumigatus cell wall: composition and biosynthesis

M Bernard, JP Latgé - Medical Mycology, 2001 - Taylor & Francis
Analysis of the cell wall of Aspergillus fumigatus is guided by obvious biological reasons: the
cell wall protects the fungus against the aggressive human defense reactions, it harbours …

The structure and synthesis of the fungal cell wall

SM Bowman, SJ Free - Bioessays, 2006 - Wiley Online Library
The fungal cell wall is a dynamic structure that protects the cell from changes in osmotic
pressure and other environmental stresses, while allowing the fungal cell to interact with its …

The fungal cell wall: structure, biosynthesis, and function

NAR Gow, JP Latge, CA Munro - Microbiology spectrum, 2017 - Am Soc Microbiol
The molecular composition of the cell wall is critical for the biology and ecology of each
fungal species. Fungal walls are composed of matrix components that are embedded and …

[HTML][HTML] Molecular organization of the alkali-insoluble fraction ofAspergillus fumigatus cell wall

T Fontaine, C Simenel, G Dubreucq, O Adam… - Journal of Biological …, 2000 - ASBMB
Physical and biological properties of the fungal cell wall are determined by the composition
and arrangement of the structural polysaccharides. Cell wall polymers of fungi are …