Angiogenesis plays an essential role in the progression of rheumatoid arthritis (RA). RGD
peptide shows high affinity and selectivity for integrin α v β 3, which is one of the most …

Rheumatoid arthritis (RA) is a chronic autoimmune disease that gravely jeopardizes the
quality of life of numerous people. Methotrexate (MTX) is a disease-modifying anti-rheumatic …

Glucocorticoids have been confirmed to be effective in the treatment of a variety of
inflammatory diseases. However, their application encounters limitations in terms of tissue …

Rheumatoid arthritis (RA) is an angiogenic and chronic inflammatory disease. One of the
most extensively used first-line drugs against RA is methotrexate (MTX), but it shows poor …

Rheumatoid arthritis (RA) is a chronic, systemic immune disease that causes joint affection
and even disability. Activated macrophages play an important role in the pathogenesis and …

Purpose: Methotrexate (MTX) is a first-line drug for rheumatoid arthritis (RA) therapy.
However, MTX monotherapy often results in irreversible joint damage due to its slow onset …

The aim of this study is to investigate in vivo anti-rheumatic activity of methotrexate-
entrapped ultradeformable liposomal gel (MTX-UDLs-gel) in adjuvant-induced arthritis rat …

Radially mesoporous silica nanoparticles (RMSNs) with protonated amine functionality are
proposed to be a dexamethasone (Dex) carrier that could achieve a sustained anti …

Macrophages can transform into M1 (pro-inflammatory) and M2 (anti-inflammatory)
phenotypes, which mediate the immune/inflammatory response in rheumatoid arthritis (RA) …

Inflammation plays an essential role in arthritis development and progression. Despite the
advances in the pharmaceutical field, current treatments still present low efficacy and severe …