Regulation of IFN signaling is critical in host recognition and response to pathogens while its
dysregulation underlies the pathogenesis of several chronic diseases. STimulator of IFN …

The innate immune system provides a primary line of defense against pathogens. Stimulator
of IFN genes (STING), encoded by the TMEM173 gene, is a critical protein involved in IFN-β …

Zika virus (ZIKV) infection can be associated with neurological pathologies, such as
microcephaly in newborns and Guillain-Barre syndrome in adults. Effective therapeutics are …

With the stimulator of IFN genes (STING) C terminus being extensively studied, the role of
the N-terminal domain (NTD) of STING remains an important subject of investigation. In this …

STING is a signaling protein encoded by the human TMEM173 gene that is central to the
host response to infection. Upon binding cyclic dinucleotides (CDNs), STING activates …

Stimulator of interferon genes (STING, also known as MITA, ERIS, or MPYS) is essential for
host immune responses triggered by microbial DNAs. However, the regulatory mechanisms …

Activation of the cyclic dinucleotide sensor stimulator of interferon (IFN) genes (STING) is
critical for IFN and inflammatory gene expression during innate immune responses …

Nearly a decade ago, an endoplasmic reticulum (ER) adaptor protein called stimulator of
interferon genes (STING) was found to be critical in the induction of type I IFN production in …

Stimulator of interferon genes (STING) is an endoplasmic reticulum–resident membrane
protein that mediates cytosolic pathogen DNA–induced innate immunity and inflammatory …

Sensing of cytosolic DNA of microbial or cellular/mitochondrial origin by cGAS initiates
innate immune responses via the adaptor protein STING. It remains unresolved how the …