The 18 kDa translocator protein, microglia and neuroinflammation

GJ Liu, RJ Middleton, CR Hatty, WWY Kam… - Brain …, 2014 - Wiley Online Library
The 18 kDa translocator protein (TSPO), previously known as the peripheral
benzodiazepine receptor, is expressed in the injured brain. It has become known as an …

Translocator protein 18 kDa (TSPO): molecular sensor of brain injury and repair

MK Chen, TR Guilarte - Pharmacology & therapeutics, 2008 - Elsevier
For over 15 years, the peripheral benzodiazepine receptor (PBR), recently named
translocator protein 18 kDa (TSPO) has been studied as a biomarker of reactive gliosis and …

Cellular sources and regional variations in the expression of the neuroinflammatory marker translocator protein (TSPO) in the normal brain

C Betlazar, M Harrison-Brown, RJ Middleton… - International Journal of …, 2018 - mdpi.com
The inducible expression of the mitochondrial translocator protein 18 kDa (TSPO) by
activated microglia is a prominent, regular feature of acute and chronic-progressive brain …

[HTML][HTML] Imaging neuroinflammation with TSPO: A new perspective on the cellular sources and subcellular localization

TR Guilarte, AN Rodichkin, JL McGlothan… - Pharmacology & …, 2022 - Elsevier
Abstract Translocator Protein 18 kDa (TSPO), previously named Peripheral Benzodiazepine
Receptor, is a well-validated and widely used biomarker of neuroinflammation to assess …

Positron emission tomography and functional characterization of a complete PBR/TSPO knockout

RB Banati, RJ Middleton, R Chan, CR Hatty… - Nature …, 2014 - nature.com
The evolutionarily conserved peripheral benzodiazepine receptor (PBR), or 18-kDa
translocator protein (TSPO), is thought to be essential for cholesterol transport and …

A quantitative neuropathological assessment of translocator protein expression in multiple sclerosis

E Nutma, JA Stephenson, RP Gorter, J de Bruin… - Brain, 2019 - academic.oup.com
The 18 kDa translocator protein (TSPO) is increasingly used to study brain and spinal cord
inflammation in degenerative diseases of the CNS such as multiple sclerosis. The enhanced …

Translocator protein is a marker of activated microglia in rodent models but not human neurodegenerative diseases

E Nutma, N Fancy, M Weinert, S Tsartsalis… - Nature …, 2023 - nature.com
Microglial activation plays central roles in neuroinflammatory and neurodegenerative
diseases. Positron emission tomography (PET) targeting 18 kDa Translocator Protein …

Fluorescence-activated cell sorting to reveal the cell origin of radioligand binding

BB Tournier, S Tsartsalis, K Ceyzériat… - Journal of Cerebral …, 2020 - journals.sagepub.com
Many studies have explored the role of TSPO (18 kDa translocator protein) as a marker of
neuroinflammation using single-photon emission computed tomography (SPECT) or …

Translocator protein 18 kDa negatively regulates inflammation in microglia

KR Bae, HJ Shim, D Balu, SR Kim, SW Yu - Journal of neuroimmune …, 2014 - Springer
Translocator protein 18 kDa (TSPO) is a mitochondrial outer membrane protein. Although
TSPO expression is up-regulated during neuroinflammation, the role of TSPO and its …

Pro-inflammatory activation of primary microglia and macrophages increases 18 kDa translocator protein expression in rodents but not humans

DR Owen, N Narayan, L Wells… - Journal of Cerebral …, 2017 - journals.sagepub.com
The 18kDa Translocator Protein (TSPO) is the most commonly used tissue-specific marker of
inflammation in positron emission tomography (PET) studies. It is expressed in myeloid cells …