The 18 kDa translocator protein, microglia and neuroinflammation
GJ Liu, RJ Middleton, CR Hatty, WWY Kam… - Brain …, 2014 - Wiley Online Library
The 18 kDa translocator protein (TSPO), previously known as the peripheral
benzodiazepine receptor, is expressed in the injured brain. It has become known as an …
benzodiazepine receptor, is expressed in the injured brain. It has become known as an …
Translocator protein 18 kDa (TSPO): molecular sensor of brain injury and repair
MK Chen, TR Guilarte - Pharmacology & therapeutics, 2008 - Elsevier
For over 15 years, the peripheral benzodiazepine receptor (PBR), recently named
translocator protein 18 kDa (TSPO) has been studied as a biomarker of reactive gliosis and …
translocator protein 18 kDa (TSPO) has been studied as a biomarker of reactive gliosis and …
Cellular sources and regional variations in the expression of the neuroinflammatory marker translocator protein (TSPO) in the normal brain
C Betlazar, M Harrison-Brown, RJ Middleton… - International Journal of …, 2018 - mdpi.com
The inducible expression of the mitochondrial translocator protein 18 kDa (TSPO) by
activated microglia is a prominent, regular feature of acute and chronic-progressive brain …
activated microglia is a prominent, regular feature of acute and chronic-progressive brain …
[HTML][HTML] Imaging neuroinflammation with TSPO: A new perspective on the cellular sources and subcellular localization
TR Guilarte, AN Rodichkin, JL McGlothan… - Pharmacology & …, 2022 - Elsevier
Abstract Translocator Protein 18 kDa (TSPO), previously named Peripheral Benzodiazepine
Receptor, is a well-validated and widely used biomarker of neuroinflammation to assess …
Receptor, is a well-validated and widely used biomarker of neuroinflammation to assess …
Positron emission tomography and functional characterization of a complete PBR/TSPO knockout
RB Banati, RJ Middleton, R Chan, CR Hatty… - Nature …, 2014 - nature.com
The evolutionarily conserved peripheral benzodiazepine receptor (PBR), or 18-kDa
translocator protein (TSPO), is thought to be essential for cholesterol transport and …
translocator protein (TSPO), is thought to be essential for cholesterol transport and …
A quantitative neuropathological assessment of translocator protein expression in multiple sclerosis
E Nutma, JA Stephenson, RP Gorter, J de Bruin… - Brain, 2019 - academic.oup.com
The 18 kDa translocator protein (TSPO) is increasingly used to study brain and spinal cord
inflammation in degenerative diseases of the CNS such as multiple sclerosis. The enhanced …
inflammation in degenerative diseases of the CNS such as multiple sclerosis. The enhanced …
Translocator protein is a marker of activated microglia in rodent models but not human neurodegenerative diseases
Microglial activation plays central roles in neuroinflammatory and neurodegenerative
diseases. Positron emission tomography (PET) targeting 18 kDa Translocator Protein …
diseases. Positron emission tomography (PET) targeting 18 kDa Translocator Protein …
Fluorescence-activated cell sorting to reveal the cell origin of radioligand binding
BB Tournier, S Tsartsalis, K Ceyzériat… - Journal of Cerebral …, 2020 - journals.sagepub.com
Many studies have explored the role of TSPO (18 kDa translocator protein) as a marker of
neuroinflammation using single-photon emission computed tomography (SPECT) or …
neuroinflammation using single-photon emission computed tomography (SPECT) or …
Translocator protein 18 kDa negatively regulates inflammation in microglia
KR Bae, HJ Shim, D Balu, SR Kim, SW Yu - Journal of neuroimmune …, 2014 - Springer
Translocator protein 18 kDa (TSPO) is a mitochondrial outer membrane protein. Although
TSPO expression is up-regulated during neuroinflammation, the role of TSPO and its …
TSPO expression is up-regulated during neuroinflammation, the role of TSPO and its …
Pro-inflammatory activation of primary microglia and macrophages increases 18 kDa translocator protein expression in rodents but not humans
DR Owen, N Narayan, L Wells… - Journal of Cerebral …, 2017 - journals.sagepub.com
The 18kDa Translocator Protein (TSPO) is the most commonly used tissue-specific marker of
inflammation in positron emission tomography (PET) studies. It is expressed in myeloid cells …
inflammation in positron emission tomography (PET) studies. It is expressed in myeloid cells …