Toward personalized medicine in connectomic deep brain stimulation

B Hollunder, N Rajamani, SH Siddiqi, C Finke… - Progress in …, 2022 - Elsevier
At the group-level, deep brain stimulation leads to significant therapeutic benefit in a
multitude of neurological and neuropsychiatric disorders. At the single-patient level …

[HTML][HTML] A novel framework for network-targeted neuropsychiatric deep brain stimulation

A Allawala, KR Bijanki, W Goodman, JF Cohn… - …, 2021 - journals.lww.com
Deep brain stimulation (DBS) has emerged as a promising therapy for neuropsychiatric
illnesses, including depression and obsessive-compulsive disorder, but has shown …

[HTML][HTML] Deep brain stimulation for psychiatric disorders: from focal brain targets to cognitive networks

CRP Sullivan, S Olsen, AS Widge - Neuroimage, 2021 - Elsevier
Deep brain stimulation (DBS) is a promising intervention for treatment-resistant psychiatric
disorders, particularly major depressive disorder (MDD) and obsessive-compulsive disorder …

[HTML][HTML] Controlling clinical states governed by different temporal dynamics with closed-loop deep brain stimulation: a principled framework

G Tinkhauser, EM Moraud - Frontiers in neuroscience, 2021 - frontiersin.org
Closed-loop strategies for deep brain stimulation (DBS) are paving the way for improving the
efficacy of existing neuromodulation therapies across neurological disorders. Unlike …

[HTML][HTML] Deep brain stimulation programming 2.0: future perspectives for target identification and adaptive closed loop stimulation

F Hell, C Palleis, JH Mehrkens, T Koeglsperger… - Frontiers in …, 2019 - frontiersin.org
Deep brain stimulation has developed into an established treatment for movement disorders
and is being actively investigated for numerous other neurological as well as psychiatric …

Closing the loop in psychiatric deep brain stimulation: physiology, psychometrics, and plasticity

AS Widge - Neuropsychopharmacology, 2024 - nature.com
Deep brain stimulation (DBS) is an invasive approach to precise modulation of
psychiatrically relevant circuits. Although it has impressive results in open-label psychiatric …

Resting-state networks link invasive and noninvasive brain stimulation across diverse psychiatric and neurological diseases

MD Fox, RL Buckner, H Liu… - Proceedings of the …, 2014 - National Acad Sciences
Brain stimulation, a therapy increasingly used for neurological and psychiatric disease,
traditionally is divided into invasive approaches, such as deep brain stimulation (DBS), and …

Closed-loop neuromodulation systems: next-generation treatments for psychiatric illness

MC Lo, AS Widge - International review of psychiatry, 2017 - Taylor & Francis
Despite deep brain stimulation's positive early results in psychiatric disorders, well-designed
clinical trials have yielded inconsistent clinical outcomes. One path to more reliable benefit …

[HTML][HTML] Landscape and future directions of machine learning applications in closed-loop brain stimulation

AS Chandrabhatla, IJ Pomeraniec, TM Horgan… - NPJ Digital …, 2023 - nature.com
Brain stimulation (BStim) encompasses multiple modalities (eg, deep brain stimulation,
responsive neurostimulation) that utilize electrodes implanted in deep brain structures to …

Probabilistic mapping of deep brain stimulation: insights from 15 years of therapy

GJB Elias, A Boutet, SE Joel, J Germann… - Annals of …, 2021 - Wiley Online Library
Deep brain stimulation (DBS) depends on precise delivery of electrical current to target
tissues. However, the specific brain structures responsible for best outcome are still debated …