Toward personalized medicine in connectomic deep brain stimulation
At the group-level, deep brain stimulation leads to significant therapeutic benefit in a
multitude of neurological and neuropsychiatric disorders. At the single-patient level …
multitude of neurological and neuropsychiatric disorders. At the single-patient level …
[HTML][HTML] A novel framework for network-targeted neuropsychiatric deep brain stimulation
Deep brain stimulation (DBS) has emerged as a promising therapy for neuropsychiatric
illnesses, including depression and obsessive-compulsive disorder, but has shown …
illnesses, including depression and obsessive-compulsive disorder, but has shown …
[HTML][HTML] Deep brain stimulation for psychiatric disorders: from focal brain targets to cognitive networks
CRP Sullivan, S Olsen, AS Widge - Neuroimage, 2021 - Elsevier
Deep brain stimulation (DBS) is a promising intervention for treatment-resistant psychiatric
disorders, particularly major depressive disorder (MDD) and obsessive-compulsive disorder …
disorders, particularly major depressive disorder (MDD) and obsessive-compulsive disorder …
[HTML][HTML] Controlling clinical states governed by different temporal dynamics with closed-loop deep brain stimulation: a principled framework
G Tinkhauser, EM Moraud - Frontiers in neuroscience, 2021 - frontiersin.org
Closed-loop strategies for deep brain stimulation (DBS) are paving the way for improving the
efficacy of existing neuromodulation therapies across neurological disorders. Unlike …
efficacy of existing neuromodulation therapies across neurological disorders. Unlike …
[HTML][HTML] Deep brain stimulation programming 2.0: future perspectives for target identification and adaptive closed loop stimulation
Deep brain stimulation has developed into an established treatment for movement disorders
and is being actively investigated for numerous other neurological as well as psychiatric …
and is being actively investigated for numerous other neurological as well as psychiatric …
Closing the loop in psychiatric deep brain stimulation: physiology, psychometrics, and plasticity
AS Widge - Neuropsychopharmacology, 2024 - nature.com
Deep brain stimulation (DBS) is an invasive approach to precise modulation of
psychiatrically relevant circuits. Although it has impressive results in open-label psychiatric …
psychiatrically relevant circuits. Although it has impressive results in open-label psychiatric …
Resting-state networks link invasive and noninvasive brain stimulation across diverse psychiatric and neurological diseases
Brain stimulation, a therapy increasingly used for neurological and psychiatric disease,
traditionally is divided into invasive approaches, such as deep brain stimulation (DBS), and …
traditionally is divided into invasive approaches, such as deep brain stimulation (DBS), and …
Closed-loop neuromodulation systems: next-generation treatments for psychiatric illness
Despite deep brain stimulation's positive early results in psychiatric disorders, well-designed
clinical trials have yielded inconsistent clinical outcomes. One path to more reliable benefit …
clinical trials have yielded inconsistent clinical outcomes. One path to more reliable benefit …
[HTML][HTML] Landscape and future directions of machine learning applications in closed-loop brain stimulation
AS Chandrabhatla, IJ Pomeraniec, TM Horgan… - NPJ Digital …, 2023 - nature.com
Brain stimulation (BStim) encompasses multiple modalities (eg, deep brain stimulation,
responsive neurostimulation) that utilize electrodes implanted in deep brain structures to …
responsive neurostimulation) that utilize electrodes implanted in deep brain structures to …
Probabilistic mapping of deep brain stimulation: insights from 15 years of therapy
Deep brain stimulation (DBS) depends on precise delivery of electrical current to target
tissues. However, the specific brain structures responsible for best outcome are still debated …
tissues. However, the specific brain structures responsible for best outcome are still debated …