Subtle longitudinal alterations in Env sequence potentiate differences in sensitivity to broadly neutralizing antibodies following acute HIV-1 subtype C infection

T Mandizvo, N Gumede, B Ndlovu, S Ndlovu… - Journal of …, 2022 - Am Soc Microbiol
Broadly neutralizing antibodies (bNAbs) for HIV-1 prevention or cure strategies must inhibit
transmitted/founder and reservoir viruses. Establishing sensitivity of circulating viruses to …

Positive selection at key residues in the HIV envelope distinguishes broad and strain-specific plasma neutralizing antibodies

BM Mabvakure, C Scheepers, N Garrett… - Journal of …, 2019 - Am Soc Microbiol
The development of HIV broadly neutralizing antibodies (bNAbs) has previously been
shown to be associated with viral evolution and high levels of genetic diversity in the HIV …

Increased breadth of HIV-1 neutralization achieved by diverse antibody clones each with limited neutralization breadth

VU Chukwuma, N Kose, DN Sather, G Sapparapu… - PLoS …, 2018 - journals.plos.org
Broadly neutralizing antibodies (bNAbs) are rarely elicited by current human
immunodeficiency virus type 1 (HIV-1) vaccine designs, but the presence of bNAbs in …

[HTML][HTML] HIV-1 neutralizing antibody response and viral genetic diversity characterized with next generation sequencing

CC Carter, GA Wagner, GK Hightower, G Caballero… - Virology, 2015 - Elsevier
To better understand the dynamics of HIV-specific neutralizing antibody (NAb), we examined
associations between viral genetic diversity and the NAb response against a multi-subtype …

New member of the V1V2-directed CAP256-VRC26 lineage that shows increased breadth and exceptional potency

NA Doria-Rose, JN Bhiman, RS Roark… - Journal of …, 2016 - Am Soc Microbiol
The epitopes defined by HIV-1 broadly neutralizing antibodies (bNAbs) are valuable
templates for vaccine design, and studies of the immunological development of these …

[HTML][HTML] Envelope characteristics in individuals who developed neutralizing antibodies targeting different epitopes in HIV-1 subtype C infection

B Ndlovu, K Gounder, D Muema, N Raju, T Hermanus… - Virology, 2020 - Elsevier
Broadly neutralizing antibodies (bNAbs) may constitute an essential component of a
protective vaccine against HIV-1, yet no immunogen has been able to elicit them. To …

Early low-titer neutralizing antibodies impede HIV-1 replication and select for virus escape

KJ Bar, C Tsao, SS Iyer, JM Decker, Y Yang… - PLoS …, 2012 - journals.plos.org
Single genome sequencing of early HIV-1 genomes provides a sensitive, dynamic
assessment of virus evolution and insight into the earliest anti-viral immune responses in …

Determinants of HIV-1 broadly neutralizing antibody induction

P Rusert, RD Kouyos, C Kadelka, H Ebner, M Schanz… - Nature medicine, 2016 - nature.com
Broadly neutralizing antibodies (bnAbs) are a focal component of HIV-1 vaccine design, yet
basic aspects of their induction remain poorly understood. Here we report on viral, host and …

A VRC13-like bNAb response is associated with complex escape pathways in HIV-1 envelope

VR Joshi, DT Claiborne, ML Pack, KA Power… - Journal of …, 2024 - Am Soc Microbiol
The rational design of HIV-1 immunogens to trigger the development of broadly neutralizing
antibodies (bNAbs) requires understanding the viral evolutionary pathways influencing this …

[HTML][HTML] Identification of amino acid substitutions associated with neutralization phenotype in the human immunodeficiency virus type-1 subtype C gp120

JL Kirchherr, J Hamilton, X Lu, S Gnanakaran… - Virology, 2011 - Elsevier
Neutralizing antibodies (Nabs) are thought to play an important role in prevention and
control of HIV-1 infection and should be targeted by an AIDS vaccine. It is critical to …