Approaches to surface engineering of extracellular vesicles

M Richter, P Vader, G Fuhrmann - Advanced drug delivery reviews, 2021 - Elsevier
Extracellular vesicles (EVs) are cell-derived nanoparticles that are important mediators in
intercellular communication. This function makes them auspicious candidates for therapeutic …

Targeted therapy using engineered extracellular vesicles: principles and strategies for membrane modification

Q Liu, D Li, X Pan, Y Liang - Journal of nanobiotechnology, 2023 - Springer
Abstract Extracellular vesicles (EVs) are 30–150 nm membrane-bound vesicles naturally
secreted by cells and play important roles in intercellular communication by delivering …

EVs and bioengineering: from cellular products to engineered nanomachines

S Villata, M Canta, V Cauda - International journal of molecular sciences, 2020 - mdpi.com
Extracellular vesicles (EVs) are natural carriers produced by many different cell types that
have a plethora of functions and roles that are still under discovery. This review aims to be a …

Generation, purification and engineering of extracellular vesicles and their biomedical applications

J Gao, X Dong, Z Wang - Methods, 2020 - Elsevier
Extracellular vesicles (EVs), derived from cell membranes, demonstrate the potential to be
excellent therapeutics and drug carriers. Although EVs are promising, the process to …

Shedding light on extracellular vesicle biogenesis and bioengineering

F Teng, M Fussenegger - Advanced Science, 2021 - Wiley Online Library
Extracellular vesicles (EVs) are biocompatible, nano‐sized secreted vesicles containing
many types of biomolecules, including proteins, RNAs, DNAs, lipids, and metabolites. Their …

Factors affecting extracellular vesicles based drug delivery systems

I Gaurav, A Thakur, A Iyaswamy, X Wang, X Chen… - Molecules, 2021 - mdpi.com
Extracellular vesicles (EVs) play major roles in intracellular communication and participate
in several biological functions in both normal and pathological conditions. Surface …

Therapeutic biomaterials based on extracellular vesicles: classification of bio-engineering and mimetic preparation routes

P García-Manrique, M Matos, G Gutiérrez… - Journal of …, 2018 - Taylor & Francis
Extracellular vesicles (EVs) are emerging as novel theranostic tools. Limitations related to
clinical uses are leading to a new research area on design and manufacture of artificial EVs …

Functional extracellular vesicles for regenerative medicine

HY Kim, S Kwon, W Um, S Shin, CH Kim, JH Park… - Small, 2022 - Wiley Online Library
The unique biological characteristics and promising clinical potential of extracellular
vesicles (EVs) have galvanized EV applications for regenerative medicine. Recognized as …

Extracellular vesicles as natural, safe and efficient drug delivery systems

F Villa, R Quarto, R Tasso - Pharmaceutics, 2019 - mdpi.com
Extracellular vesicles (EVs) are particles naturally released from cells, delimited by a lipid
bilayer, carrying functionally active biological molecules. In addition to their physiological …

New approaches in extracellular vesicle engineering for improving the efficacy of anti-cancer therapies

MK Jayasinghe, M Tan, B Peng, Y Yang, G Sethi… - Seminars in Cancer …, 2021 - Elsevier
Cancer is a disease that evolves continuously with unpredictable outcomes. Although
conventional chemotherapy can display significant antitumor effects, the lack of specificity …