Erythropoiesis occurs mostly in bone marrow and ends in blood stream. Mature red blood
cells are generated from multipotent hematopoietic stem cells, through a complex maturation …

Wholesale depletion of membrane organelles and extrusion of the nucleus are hallmarks of
mammalian erythropoiesis. Using quantitative EM and fluorescence imaging we have …

Mitochondrial clearance is a well recognized but poorly understood biologic process, and
reticulocytes, which undergo programmed mitochondrial clearance, provide a useful model …

During the differentiation of erythroid cells, a vast program of maturation takes place, leading
to decay or elimination of organelles, including the nucleus, mitochondria, ribosomes …

Timely elimination of damaged mitochondria is essential to protect cells from the potential
harm of disordered mitochondrial metabolism and release of proapoptotic proteins. In …

Production of a red blood cell's hemoglobin depends on mitochondrial heme synthesis.
However, mature red blood cells are devoid of mitochondria and rely on glycolysis for ATP …

The final steps of erythropoiesis involve unique cellular processes including enucleation
and reorganization of membrane proteins and the cytoskeleton to produce biconcave …

Red blood cells (RBCs), which constitute the most abundant cell type in the body, come in
two distinct flavors-primitive and definitive. Definitive RBCs in mammals circulate as smaller …

A characteristic feature of terminal erythropoiesis in mammals is extrusion of the highly
condensed nucleus out of the cytoplasm. Other vertebrates, including fish, reptiles …

Macroautophagy is a highly conserved intracellular process responsible for the degradation
of subcellular constituents. Macroautophagy was recently suggested to be involved in the …