Hollow prussian blue nanozymes drive neuroprotection against ischemic stroke via attenuating oxidative stress, counteracting inflammation, and suppressing cell …

K Zhang, M Tu, W Gao, X Cai, F Song, Z Chen… - Nano …, 2019 - ACS Publications
Ischemic stroke is a devastating disease and one of the leading causes of mortality
worldwide. Overproduction of reactive oxygen and nitrogen species (RONS) following …

Neutrophil-like cell-membrane-coated nanozyme therapy for ischemic brain damage and long-term neurological functional recovery

L Feng, C Dou, Y Xia, B Li, M Zhao, P Yu, Y Zheng… - ACS …, 2021 - ACS Publications
Oxidative stress and a series of excessive inflammatory responses are major obstacles for
neurological functional recovery after ischemic stroke. Effective noninvasive anti …

Prussian blue nanozyme as a pyroptosis inhibitor alleviates neurodegeneration

X Ma, J Hao, J Wu, Y Li, X Cai, Y Zheng - Advanced Materials, 2022 - Wiley Online Library
Current pharmacological interventions for Parkinson's disease (PD) remain unsatisfactory in
clinical settings. Inflammasome‐mediated pyroptosis represents a potential therapeutic …

Bioactive nanoenzyme reverses oxidative damage and endoplasmic reticulum stress in neurons under ischemic stroke

G Huang, J Zang, L He, H Zhu, J Huang, Z Yuan… - ACS …, 2021 - ACS Publications
Designing translational antioxidative agents that could scavenge free radicals produced
during reperfusion in brain ischemia stroke and alleviate neurologic damage is the main …

Carbogenic nanozyme with ultrahigh reactive nitrogen species selectivity for traumatic brain injury

X Mu, H He, J Wang, W Long, Q Li, H Liu, Y Gao… - Nano Letters, 2019 - ACS Publications
Reactive oxygen and nitrogen species (RONS), especially reactive nitrogen species (RNS)
are intermediate products during incidence of nervous system diseases, showing …

Comprehensive insights into the multi-antioxidative mechanisms of melanin nanoparticles and their application to protect brain from injury in ischemic stroke

Y Liu, K Ai, X Ji, D Askhatova, R Du… - Journal of the American …, 2017 - ACS Publications
Nanotechnology-mediated antioxidative therapy is emerging as a novel strategy for treating
a myriad of important diseases through scavenging excessive reactive oxygen and nitrogen …

[HTML][HTML] Brain-targeting, acid-responsive antioxidant nanoparticles for stroke treatment and drug delivery

S Zhang, B Peng, Z Chen, J Yu, G Deng, Y Bao, C Ma… - Bioactive materials, 2022 - Elsevier
Stroke is the leading cause of death and disability. Currently, there is no effective
pharmacological treatment for this disease, which can be partially attributed to the inability to …

Nanozyme‐enabled treatment of cardio‐and cerebrovascular diseases

Y Zhang, W Liu, X Wang, Y Liu, H Wei - Small, 2023 - Wiley Online Library
Cardio‐and cerebrovascular diseases are two major vascular‐related diseases that lead to
death worldwide. Reactive oxygen species (ROS) play a vital role in the occurrence and …

A thrombin‐activated peptide‐templated nanozyme for remedying ischemic stroke via thrombolytic and neuroprotective actions

Z Wang, Y Zhao, Y Hou, G Tang, R Zhang… - Advanced …, 2024 - Wiley Online Library
Ischemic stroke (IS) is one of the most common causes of disability and death. Thrombolysis
and neuroprotection are two current major therapeutic strategies to overcome ischemic and …

A Co-Doped Fe3O4 Nanozyme Shows Enhanced Reactive Oxygen and Nitrogen Species Scavenging Activity and Ameliorates the Deleterious Effects of Ischemic …

Y Liu, X Wang, X Li, S Qiao, G Huang… - … Applied Materials & …, 2021 - ACS Publications
Acute ischemic stroke has become the major cause of mortality and disability worldwide.
Following ischemic stroke, the reperfusion injury is mainly mediated by the burst of reactive …