[HTML][HTML] Identification of vulnerable cell types in major brain disorders using single cell transcriptomes and expression weighted cell type enrichment
The cell types that trigger the primary pathology in many brain diseases remain largely
unknown. One route to understanding the primary pathological cell type for a particular …
unknown. One route to understanding the primary pathological cell type for a particular …
[HTML][HTML] Cross-laboratory analysis of brain cell type transcriptomes with applications to interpretation of bulk tissue data
Establishing the molecular diversity of cell types is crucial for the study of the nervous
system. We compiled a cross-laboratory database of mouse brain cell type-specific …
system. We compiled a cross-laboratory database of mouse brain cell type-specific …
[HTML][HTML] Single nucleus multi-omics identifies human cortical cell regulatory genome diversity
Single-cell technologies measure unique cellular signatures but are typically limited to a
single modality. Computational approaches allow the fusion of diverse single-cell data …
single modality. Computational approaches allow the fusion of diverse single-cell data …
[HTML][HTML] Revealing cell vulnerability in Alzheimer's disease by single-cell transcriptomics
CA Saura, A Deprada, MD Capilla-López… - Seminars in cell & …, 2023 - Elsevier
Alzheimer's disease (AD) is a neurodegenerative disorder that by affecting specific brain cell
types and regions cause severe pathological and functional changes in memory neural …
types and regions cause severe pathological and functional changes in memory neural …
A cell epigenotype specific model for the correction of brain cellular heterogeneity bias and its application to age, brain region and major depression
Brain cellular heterogeneity may bias cell type specific DNA methylation patterns,
influencing findings in psychiatric epigenetic studies. We performed fluorescence activated …
influencing findings in psychiatric epigenetic studies. We performed fluorescence activated …
[HTML][HTML] Inference of cell type content from human brain transcriptomic datasets illuminates the effects of age, manner of death, dissection, and psychiatric diagnosis
Psychiatric illness is unlikely to arise from pathology occurring uniformly across all cell types
in affected brain regions. Despite this, transcriptomic analyses of the human brain have …
in affected brain regions. Despite this, transcriptomic analyses of the human brain have …
Cell-type-specific cis-eQTLs in eight human brain cell types identify novel risk genes for psychiatric and neurological disorders
To date, most expression quantitative trait loci (eQTL) studies, which investigate how genetic
variants contribute to gene expression, have been performed in heterogeneous brain …
variants contribute to gene expression, have been performed in heterogeneous brain …
[HTML][HTML] eFORGE: a tool for identifying cell type-specific signal in epigenomic data
Epigenome-wide association studies (EWAS) provide an alternative approach for studying
human disease through consideration of non-genetic variants such as altered DNA …
human disease through consideration of non-genetic variants such as altered DNA …
[HTML][HTML] Single-cell RNA sequencing analysis of human Alzheimer's disease brain samples reveals neuronal and glial specific cells differential expression
Alzheimer's disease is the most common neurological disease worldwide. Unfortunately,
there are currently no effective treatment methods nor early detection methods. Furthermore …
there are currently no effective treatment methods nor early detection methods. Furthermore …
[HTML][HTML] Deconvolving the contributions of cell-type heterogeneity on cortical gene expression
Complexity of cell-type composition has created much skepticism surrounding the
interpretation of bulk tissue transcriptomic studies. Recent studies have shown that …
interpretation of bulk tissue transcriptomic studies. Recent studies have shown that …