Adverse events, response failures and medication non-compliance are common in patients
receiving medications for the treatment of mental illnesses. A systematic literature review …

Numerous studies in the field of psychopharmacological treatment have investigated the
possible contribution of genetic variability between individuals to differences in drug efficacy …

Genetic testing may help to improve treatment outcomes in order to avoid non-response or
severe side effects to psychotropic medication. Most robust data have been obtained for …

Antidepressants are commonly prescribed medications in the United States, and there is
increasing interest in individualizing treatment selection for more than 20 US Food and Drug …

Individuals carrying genetic variants that result in non-extensive CYP2D6 and CYP2C19
enzyme activity seem to be more prone to non-response and side-effects of psychotropic …

The specific reaction toward a given drug varies a lot between individuals and, for many
drugs, pharmacogenetic polymorphisms are known to affect biotransformation and clinical …

A critical review of the limited available evidence and the authors' experience and judgment
are used to summarize the role of cytochrome P450 (CYP) genetic variants in the …

Purpose: Cytochrome P450 (CYP450) enzymes metabolize selective serotonin reuptake
inhibitor (SSRI) drugs used in treatment of depression. Variants in these genes may impact …

In psychiatry, around 130 drugs are available which have been detected and developed
during the last 60 years. These drugs are effective and essential for the treatment of many …

Importance Precise estimation of the drug metabolism capacity for individual patients is
crucial for adequate dose personalization. Objective To quantify the difference in the …