Accumulating evidence indicates that asymptomatic hyperuricemia is involved in the
development of hypertension and chronic kidney disease. A 2-hit model has been proposed …

Asymptomatic hyperuricemia is frequently observed in patients with kidney disease.
Although a substantial number of epidemiologic studies have suggested that an elevated …

Although hyperuricemia has long been associated with renal disease, uric acid has not
been considered as a true mediator of progression of renal disease. The observation that …

Results: The causes for hyperuricemia in overproducers may be either exogenous or
endogenous. CKD has become a global public health problem because of its high …

Hyperuricemia (elevated serum uric acid) is prevalent, and an important mediator of gout, an
increasingly common condition. In addition, hyperuricemia is associated with metabolic …

The relationship between hyperuricemia, gout, and renal disease has been investigated for
several years. From the beginning, kidney disease has been considered a complication of …

Uric acid is a product of purine metabolism and has been linked to gout and kidney calculi.
Chronic kidney disease (CKD) and hypertension (HTN) are two major public health …

Hyperuricemia is particularly common in patients with arterial hypertension, metabolic
syndrome, or kidney disease. Its role, however, as a risk factor for both renal and …

The prevalence of chronic kidney disease (CKD) has increased and will continue to
increase in the United States and worldwide. This is alarming considering that CKD is an …

Abstract Purpose of Review In chronic kidney disease (CKD), plasma uric acid levels are
increased because of the decrease in glomerular filtration rate. However, in addition to CKD …