Background The onset of puberty is first detected as an increase in pulsatile secretion of
gonadotropin-releasing hormone (GnRH). Early activation of the hypothalamic–pituitary …

Context: Loss-of-function mutations in makorin ring finger 3 (MKRN3), an imprinted gene
located on the long arm of chromosome 15, have been recognized recently as a cause of …

Context and objective Idiopathic central precocious puberty (iCPP) is defined as early
activation of the hypothalamic–pituitary–gonadal axis in the absence of identifiable central …

A pivotal event in the onset of puberty in humans is the reemergence of the pulsatile release
of the gonadotropin-releasing hormone (GnRH) from hypothalamic neurons. Pathways …

Context Loss-of-function mutations of makorin RING finger protein 3 (MKRN3) are the most
common monogenic cause of familial central precocious puberty (CPP). Objective To …

Context: Central precocious puberty (CPP), defined as the development of secondary sex
characteristics prior to age 8 years in girls and 9 years in boys, results from the premature …

Background/Aims: Recently, loss-of-function mutations in the MKRN3 gene have been
implicated in the etiology of familial central precocious puberty (CPP) in both sexes. We …

Pubertal timing is regulated by the complex interplay of genetic, environmental, nutritional
and epigenetic factors. Criteria for determining normal pubertal timing, and thus the …

Pubertal timing in humans is determined by complex interactions including hormonal,
metabolic, environmental, ethnic, and genetic factors. Central precocious puberty (CPP) is …

Context: Central precocious puberty (CPP) results from premature activation of the
hypothalamic–pituitary–gonadal axis. Few genetic causes of CPP have been identified, with …