Background Tissue inhibitor of metalloproteinase 3 (TIMP3) was recently demonstrated
capable to regulate some gene expression in a myocardial infarction model. Here we aim to …

Tissue inhibitor of matrix metalloprotease 4 (TIMP 4) is endogenously one of the key
modulators of matrix metalloprotease 9 (MMP 9) and we have reported earlier that cardiac …

Abstract Background TIMP4 (Tissue Inhibitors of Matrix Metalloprotease 4), goes down in
failing hearts and mice lacking TIMP4 show poor regeneration capacity after myocardial …

Tissue inhibitor of metalloproteinase 3 (TIMP3) is unique among the four TIMPs due to its
extracellular matrix (ECM)-binding property and broad range of inhibitory substrates that …

Background/Aims: Myocardial ischemia/reperfusion (I/R) injury remains a great challenge in
clinical therapy. Tissue inhibitor of metalloproteinases 3 (TIMP3) plays a crucial role in heart …

Tissue inhibitor of metalloproteinase 3 (TIMP3) is a protease with high expression levels in
the heart and plays an essential role in extracellular matrix turnover by maintaining …

Myocardial infarction (MI) results in loss of cardiomyocytes, adverse extracellular matrix
(ECM) and structural remodeling, and left ventricular (LV) dilation and dysfunction. Tissue …

Tissue inhibitors of matrix metalloproteinases (TIMPs) comprise a family of four members, of
which TIMP4 is characterized by being primarily restricted to cardiovascular structures. We …

We have recently demonstrated that tissue inhibitor of metalloproteinase-3 (TIMP-3)
decreases neonatal cardiomyocyte proliferation (Hammoud L, Xiang F, Lu X, Brunner F …

Aims Tissue inhibitor of metalloproteinases (TIMPs) can mediate myocardial remodelling,
hypertrophy, and fibrosis in heart disease. We investigated the impact of TIMP2 vs. TIMP3 …