Transient receptor potential channels as therapeutic targets

MM Moran, MA McAlexander, T Bíró… - Nature reviews Drug …, 2011 - nature.com
Transient receptor potential (TRP) cation channels have been among the most aggressively
pursued drug targets over the past few years. Although the initial focus of research was on …

Transient receptor potential channels as drug targets: from the science of basic research to the art of medicine

B Nilius, A Szallasi - Pharmacological reviews, 2014 - ASPET
The large Trp gene family encodes transient receptor potential (TRP) proteins that form
novel cation-selective ion channels. In mammals, 28 Trp channel genes have been …

Advances in TRP channel drug discovery: from target validation to clinical studies

AP Koivisto, MG Belvisi, R Gaudet… - Nature reviews Drug …, 2022 - nature.com
Transient receptor potential (TRP) channels are multifunctional signalling molecules with
many roles in sensory perception and cellular physiology. Therefore, it is not surprising that …

Transient receptor potential (TRP) channels: a clinical perspective

Y Kaneko, A Szallasi - British journal of pharmacology, 2014 - Wiley Online Library
Transient receptor potential (TRP) channels are important mediators of sensory signals with
marked effects on cellular functions and signalling pathways. Indeed, mutations in genes …

International Union of Basic and Clinical Pharmacology. LXXVI. Current progress in the mammalian TRP ion channel family

LJ Wu, TB Sweet, DE Clapham - Pharmacological reviews, 2010 - ASPET
Transient receptor potential (TRP) channels are a large family of ion channel proteins,
surpassed in number in mammals only by voltage-gated potassium channels. TRP channels …

Transient receptor potential cation channels in disease

B Nilius, G Owsianik, T Voets… - Physiological …, 2007 - journals.physiology.org
The transient receptor potential (TRP) superfamily consists of a large number of cation
channels that are mostly permeable to both monovalent and divalent cations. The 28 …

TRP channels and Ca2+ signaling

B Minke - Cell calcium, 2006 - Elsevier
There is a rapidly growing interest in the family of transient receptor potential (TRP)
channels because TRP channels are not only important for many sensory systems, but they …

Transient receptor potential channels and calcium signaling

L Vangeel, T Voets - Cold Spring Harbor perspectives in …, 2019 - cshperspectives.cshlp.org
Transient receptor potential (TRP) cation channels play diverse roles in cellular Ca2+
signaling. First, as Ca2+-permeable channels that respond to a variety of stimuli, TRP …

Transient receptor potential channels: targeting pain at the source

A Patapoutian, S Tate, CJ Woolf - Nature reviews Drug discovery, 2009 - nature.com
Pain results from the complex processing of neural signals at different levels of the central
nervous system, with each signal potentially offering multiple opportunities for …

TRP (transient receptor potential) ion channel family: Structures, biological functions and therapeutic interventions for diseases

M Zhang, Y Ma, X Ye, N Zhang, L Pan… - Signal Transduction and …, 2023 - nature.com
Transient receptor potential (TRP) channels are sensors for a variety of cellular and
environmental signals. Mammals express a total of 28 different TRP channel proteins, which …