Metformin is one of the most widely prescribed hypoglycemic drugs and has the potential to
treat many diseases. More and more evidence shows that metformin can regulate the …

Metformin is a biguanide family member used in the treatment of type 2 diabetes and one of
the most widely prescribed antidiabetes drugs. This drug increases the peripheral uptake of …

The biguanide metformin is the most commonly used antidiabetic drug. Recent studies show
that metformin not only improves chronic inflammation by improving metabolic parameters …

Background: Metformin, a widely prescribed blood glucose normalizing antidiabetic drug, is
now beginning to receive increasing attention due to its anti-inflammatory properties …

Objective—Metformin may benefit the macrovascular complications of diabetes
independently of its conventional hypoglycemic effects. Accumulating evidence suggests …

Metformin is an oral hypoglycemic agent which is most widely used as first-line therapy for
type 2 diabetes. Metformin improves hyperglycemia by suppressing hepatic glucose …

Background Diabetic patients experience accelerated atherosclerosis. Metformin is a
cornerstone of the current therapy of type 2 diabetes. Macrophages are the key cells …

Rationale: The diabetes mellitus drug metformin is under investigation in cardiovascular
disease, but the molecular mechanisms underlying possible benefits are poorly understood …

Background Metformin has good anti-hyperglycemic effectiveness, but does not induce
hypoglycemia, is very safe, and has become the preferred drug for the treatment of type 2 …

Aims Atherosclerotic vascular disease has an inflammatory pathogenesis. Heme from
intraplaque haemorrhage may drive a protective and pro-resolving macrophage M2-like …