Extracellular purines (adenosine, ADP, and ATP) and pyrimidines (UDP and UTP) are
important signaling molecules that mediate diverse biological effects via cellsurface …

Membrane receptors that are activated by the purine nucleoside adenosine (adenosine
receptors) or by purine or pyrimidine nucleotides (P2Y and P2X receptors) transduce …

In the last decade, the field of purinergic pharmacology has continued to grow as the
complexity of the receptor families and the various enzymes involved in purine metabolism …

Physiological evidence supporting the role of the adenine nucleotide, ATP 1 (Figure 1), as a
neurotransmitter was first summarized in detail in 1972, 1 representing the basis of …

The purine nucleoside adenosine and the purine nucleotide ATP play different roles in the
nervous system. Adenosine acts on a family of G protein coupled receptors, collectively …

The classification of receptors for adenosine, ATP and ADP (collectively called
purinoceptors) has seen a number of developments in the past three years. The important …

Adenosine 5′-triphosphate (ATP), in addition to its intracellular roles, acts as an
extracellular signalling molecule via a rich array of receptors, which have been cloned and …

In the field of purinoceptors, the P1‐adenosine and P2‐ATP system proposed by Burnstock
some 15 years ago has provided a cornerstone for receptor nomenclature [Burnstock and …

Pharmacological tool compounds are now available to define action at the adenosine (ARs),
P2Y and P2X receptors. We present a selection of the most commonly used agents to study …

The medicinal chemistry and pharmacology of the four subtypes of adenosine receptors
(ARs) and the eight subtypes of P2Y receptors (P2YRs, activated by a range of purine and …