The GH/IGF1 system, like other endocrine systems, is dynamic and its activity changes with
age and sexual maturation, and is influenced by body composition and other factors. A …

Impaired GH activity at target tissues, occurring when GH action is blocked or during
suboptimal GH replacement therapy, may result in a pathological state associated with …

Summary Introduction and Background Normative data for the iSYS IGF‐I assay have been
published both in the VARIETE cohort and by Bidlingmaier et al. Objective To investigate …

Context: IGF-1 measurements are used for screening and monitoring GH deficiency (GHD)
and acromegaly. Objective: Our objective was to study whether the introduction of the IDS …

Objective The regulation of IGF-I levels is complex and not only dependent on GH status, as
the diagnostic sensitivity of serum IGF-I levels for GH deficiency (GHD) in adults is low. Other …

Objective To analyse the diagnostic role of serum IGF-I, IGF-binding protein-3 (IGFBP-3), IGF-
I/IGFBP-3 molar ratio and urinary GH (uGH) excretion in adult GH deficiency (GHD). Design …

Objective Clinical response to GH therapy in GH-deficient (GHD) adults varies widely. Good
predictors of treatment response are lacking. The aim of the study was to develop …

Objective At diagnosis, approximately 50% of adults with severe GH deficiency (GHD) have
an IGF‐I within the reference range. It is unclear whether in such patients serum IGF‐I levels …

Objective We studied whether the severity of GH deficiency (GHD) defined as i) GH-peak on
stimulation tests (insulin tolerance test (ITT), arginine, and glucagon), ii) number of …

Objective To evaluate the impact of different peak GH cut-off limits after GHRH-Arg test, IGF1
measurement, or their combination in identifying patients with GH deficit (GHD). Design and …