Exosomal miRNAs as cancer biomarkers and therapeutic targets

A Thind, C Wilson - Journal of extracellular vesicles, 2016 - Taylor & Francis
Intercommunication between cancer cells and with their surrounding and distant
environments is key to the survival, progression and metastasis of the tumour. Exosomes …

Effect of exosomal miRNA on cancer biology and clinical applications

Z Sun, K Shi, S Yang, J Liu, Q Zhou, G Wang, J Song… - Molecular cancer, 2018 - Springer
Exosomes, extracellular vesicles with diameters ranging from 30 to 150 nm, are widely
present in various body fluids. Recently, microRNAs (miRNAs) have been identified in …

Expression, regulation, and function of exosome‐derived miRNAs in cancer progression and therapy

B Li, Y Cao, M Sun, H Feng - The FASEB Journal, 2021 - Wiley Online Library
Exosomes are a novel class of intercellular signal modulators that contain a wide range of
molecules and deliver information between cells and tissues. MicroRNAs (miRNAs), a type …

Emerging function and clinical values of exosomal microRNAs in cancer

M Wang, F Yu, H Ding, Y Wang, P Li, K Wang - Molecular therapy-Nucleic …, 2019 - cell.com
Exosomes are a subset of membrane-bound extracellular vesicles with diameters ranging
from 30 to 100 nm. Exosomes enclose a variety of molecules, such as lipids, proteins, and …

Exosomal miRNAs as novel cancer biomarkers: Challenges and opportunities

M Salehi, M Sharifi - Journal of cellular physiology, 2018 - Wiley Online Library
A biomarker with high specificity and sensitivity, is a basic requirement for non‐invasive
cancer diagnosis. Exosomes are a type of lipid bilayer extracellular vesicles (EVs) …

The clinical relevance of circulating, exosomal miRNAs as biomarkers for cancer

H Schwarzenbach - Expert review of molecular diagnostics, 2015 - Taylor & Francis
In cancer, deregulated expression levels of miRNAs are associated with tumorigenesis,
tumor progression, metastasis and drug resistance. Apart from their release by apoptotic and …

Exosome and exosomal microRNA: trafficking, sorting, and function

J Zhang, S Li, L Li, M Li, C Guo, J Yao… - Genomics, Proteomics …, 2015 - academic.oup.com
Abstract Exosomes are 40–100 nm nano-sized vesicles that are released from many cell
types into the extracellular space. Such vesicles are widely distributed in various body fluids …

MicroRNAs transported by exosomes in body fluids as mediators of intercellular communication in cancer

I Salido-Guadarrama, S Romero-Cordoba… - OncoTargets and …, 2014 - Taylor & Francis
Cancer-cell communication is an important and complex process, achieved through a
diversity of mechanisms that allows tumor cells to mold and influence their environment. In …

The role of Exosomal miRNAs in cancer

C Li, T Zhou, J Chen, R Li, H Chen, S Luo… - Journal of translational …, 2022 - Springer
Exosomal miRNAs have attracted much attention due to their critical role in regulating genes
and the altered expression of miRNAs in virtually all cancers affecting humans (Sun et al. in …

The role of exo-miRNAs in cancer: a focus on therapeutic and diagnostic applications

F Ingenito, G Roscigno, A Affinito, S Nuzzo… - International journal of …, 2019 - mdpi.com
Exosomes are extracellular vesicles released into biological fluids where they act as carriers
of various molecules, including proteins, lipids, and RNAs, between cells, modulating or …