[HTML][HTML] Adhesion strength and contractility enable metastatic cells to become adurotactic
Significant changes in cell stiffness, contractility, and adhesion, ie, mechanotype, are
observed during a variety of biological processes. Whether cell mechanics merely change …
observed during a variety of biological processes. Whether cell mechanics merely change …
[HTML][HTML] Durotaxis by human cancer cells
BJ DuChez, AD Doyle, EK Dimitriadis, KM Yamada - Biophysical journal, 2019 - cell.com
Durotaxis is a type of directed cell migration in which cells respond to a gradient of
extracellular stiffness. Using automated tracking of positional data for large sample sizes of …
extracellular stiffness. Using automated tracking of positional data for large sample sizes of …
[HTML][HTML] Negative durotaxis: cell movement toward softer environments
How cells sense tissue stiffness to guide cell migration is a fundamental question in
development, fibrosis and cancer. Although durotaxis–traditionally defined as cell migration …
development, fibrosis and cancer. Although durotaxis–traditionally defined as cell migration …
Directed cell migration towards softer environments
How cells sense tissue stiffness to guide cell migration is a fundamental question in
development, fibrosis and cancer. Although durotaxis—cell migration towards increasing …
development, fibrosis and cancer. Although durotaxis—cell migration towards increasing …
Guiding cell migration by tugging
SV Plotnikov, CM Waterman - Current opinion in cell biology, 2013 - Elsevier
The ability of cells to move directionally toward areas of stiffer extracellular matrix (ECM) via
a process known as 'durotaxis' is thought to be critical for development and wound healing …
a process known as 'durotaxis' is thought to be critical for development and wound healing …
Collective cell durotaxis emerges from long-range intercellular force transmission
The ability of cells to follow gradients of extracellular matrix stiffness—durotaxis—has been
implicated in development, fibrosis, and cancer. Here, we found multicellular clusters that …
implicated in development, fibrosis, and cancer. Here, we found multicellular clusters that …
[HTML][HTML] Positive, negative and controlled durotaxis
P Sáez, C Venturini - Soft matter, 2023 - pubs.rsc.org
Cell migration is a physical process central to life. Among others, it regulates
embryogenesis, tissue regeneration, and tumor growth. Therefore, understanding and …
embryogenesis, tissue regeneration, and tumor growth. Therefore, understanding and …
Stiffness-dependent active wetting enables optimal collective cell durotaxis
The directed migration of cellular clusters enables morphogenesis, wound healing and
collective cancer invasion. Gradients of substrate stiffness direct the migration of cellular …
collective cancer invasion. Gradients of substrate stiffness direct the migration of cellular …
[HTML][HTML] Force fluctuations within focal adhesions mediate ECM-rigidity sensing to guide directed cell migration
Cell migration toward areas of higher extracellular matrix (ECM) rigidity via a process called"
durotaxis" is thought to contribute to development, immune response, and cancer …
durotaxis" is thought to contribute to development, immune response, and cancer …
Adhesion dynamics and durotaxis in migrating cells
When tissue cells are plated on a flexible substrate, durotaxis, the directed migration of cells
towards mechanically stiff regions, has been observed. Environmental mechanical signals …
towards mechanically stiff regions, has been observed. Environmental mechanical signals …